3rlq
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3rlq is ON HOLD Authors: Kung, P-P., Sinnema, P-J., Richardson, P., Hickey, M.J., Gajiwala, K.S., Wang, F., Huang, B., McClellan, G., Wang, J., Maeg...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5- carbonitrile== | |
| + | <StructureSection load='3rlq' size='340' side='right'caption='[[3rlq]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3rlq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RLQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3RQ:4-(2,4-DICHLORO-5-METHOXYPHENYL)-2-METHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONITRILE'>3RQ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rlq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rlq OCA], [https://pdbe.org/3rlq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rlq RCSB], [https://www.ebi.ac.uk/pdbsum/3rlq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rlq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bergqvist S]] | ||
| + | [[Category: Gajiwala KS]] | ||
| + | [[Category: Hickey MJ]] | ||
| + | [[Category: Huang B]] | ||
| + | [[Category: Kania R]] | ||
| + | [[Category: Kung P-P]] | ||
| + | [[Category: Maegley K]] | ||
| + | [[Category: McClellan G]] | ||
| + | [[Category: Mehta PP]] | ||
| + | [[Category: Richardson P]] | ||
| + | [[Category: Sinnema P-J]] | ||
| + | [[Category: Wang F]] | ||
| + | [[Category: Wang J]] | ||
Current revision
Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5- carbonitrile
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Categories: Homo sapiens | Large Structures | Bergqvist S | Gajiwala KS | Hickey MJ | Huang B | Kania R | Kung P-P | Maegley K | McClellan G | Mehta PP | Richardson P | Sinnema P-J | Wang F | Wang J
