3ajl

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[[Image:3ajl.jpg|left|200px]]
 
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==Crystal structure of d(CGCGGATf5UCGCG): 5-Formyluridine:guanosine Base-pair in B-DNA with DAPI==
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The line below this paragraph, containing "STRUCTURE_3ajl", creates the "Structure Box" on the page.
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<StructureSection load='3ajl' size='340' side='right'caption='[[3ajl]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ajl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AJL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAP:6-AMIDINE-2-(4-AMIDINO-PHENYL)INDOLE'>DAP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UFR:2-DEOXY-5-FORMYLURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>UFR</scene></td></tr>
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{{STRUCTURE_3ajl| PDB=3ajl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ajl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ajl OCA], [https://pdbe.org/3ajl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ajl RCSB], [https://www.ebi.ac.uk/pdbsum/3ajl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ajl ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hydroxyl radicals are potent mutagens that attack DNA to form various base and ribose derivatives. One of the major damaged thymine derivatives is 5-formyluracil (fU), which induces pyrimidine transition during replication. In order to establish the structural basis for such mutagenesis, the crystal structures of two kinds of DNA d(CGCGRATfUCGCG) with R = A/G have been determined by X-ray crystallography. The fU residues form a Watson-Crick-type pair with A and two types of pairs (wobble and reversed wobble) with G, the latter being a new type of base pair between ionized thymine base and guanine base. In silico structural modeling suggests that the DNA polymerase can accept the reversed wobble pair with G, as well as the Watson-Crick pair with A.
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===Crystal structure of d(CGCGGATf5UCGCG): 5-Formyluridine:guanosine Base-pair in B-DNA with DAPI===
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Insights into the structures of DNA damaged by hydroxyl radical: crystal structures of DNA duplexes containing 5-formyluracil.,Tsunoda M, Sakaue T, Naito S, Sunami T, Abe N, Ueno Y, Matsuda A, Takenaka A J Nucleic Acids. 2010 Oct 7;2010:107289. PMID:20976303<ref>PMID:20976303</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ajl" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20976303 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20976303}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3ajl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJL OCA].
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[[Category: Matsuda A]]
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[[Category: Sakaue T]]
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==Reference==
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[[Category: Takenaka A]]
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<ref group="xtra">PMID:20976303</ref><references group="xtra"/>
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[[Category: Tsunoda M]]
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[[Category: Matsuda, A.]]
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[[Category: Ueno Y]]
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[[Category: Sakaue, T.]]
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[[Category: Takenaka, A.]]
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[[Category: Tsunoda, M.]]
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[[Category: Ueno, Y.]]
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Current revision

Crystal structure of d(CGCGGATf5UCGCG): 5-Formyluridine:guanosine Base-pair in B-DNA with DAPI

PDB ID 3ajl

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