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3q8l

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[[Image:3q8l.jpg|left|200px]]
 
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==Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with substrate 5'-flap DNA, SM3+, and K+==
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The line below this paragraph, containing "STRUCTURE_3q8l", creates the "Structure Box" on the page.
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<StructureSection load='3q8l' size='340' side='right'caption='[[3q8l]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3q8l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q8L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.319&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3q8l| PDB=3q8l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q8l OCA], [https://pdbe.org/3q8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q8l RCSB], [https://www.ebi.ac.uk/pdbsum/3q8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q8l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FEN1_HUMAN FEN1_HUMAN] Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.<ref>PMID:7961795</ref> <ref>PMID:8621570</ref> <ref>PMID:10744741</ref> <ref>PMID:11986308</ref> <ref>PMID:18443037</ref> <ref>PMID:20729856</ref>
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===Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with substrate 5'-flap DNA, SM3+, and K+===
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==See Also==
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21496641}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21496641 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21496641}}
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==About this Structure==
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[[3q8l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8L OCA].
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==Reference==
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<ref group="xtra">PMID:21496641</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arvai, A.]]
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[[Category: Large Structures]]
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[[Category: Chapados, B R.]]
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[[Category: Arvai A]]
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[[Category: Classen, S.]]
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[[Category: Chapados BR]]
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[[Category: Cooper, P K.]]
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[[Category: Classen S]]
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[[Category: Finger, D L.]]
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[[Category: Cooper PK]]
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[[Category: Grasby, J A.]]
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[[Category: Finger DL]]
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[[Category: Guenther, G.]]
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[[Category: Grasby JA]]
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[[Category: Sarker, A H.]]
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[[Category: Guenther G]]
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[[Category: Shen, B.]]
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[[Category: Sarker AH]]
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[[Category: Tainer, J A.]]
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[[Category: Shen B]]
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[[Category: Thompson, P.]]
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[[Category: Tainer JA]]
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[[Category: Tomlinson, C G.]]
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[[Category: Thompson P]]
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[[Category: Tsutakawa, S E.]]
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[[Category: Tomlinson CG]]
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[[Category: Tsutakawa SE]]

Current revision

Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with substrate 5'-flap DNA, SM3+, and K+

PDB ID 3q8l

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