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3rep

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[[Image:3rep.jpg|left|200px]]
 
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==Crystal structure of the ILK/alpha-parvin core complex (MnATP)==
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The line below this paragraph, containing "STRUCTURE_3rep", creates the "Structure Box" on the page.
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<StructureSection load='3rep' size='340' side='right'caption='[[3rep]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rep]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3REP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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{{STRUCTURE_3rep| PDB=3rep | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rep OCA], [https://pdbe.org/3rep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rep RCSB], [https://www.ebi.ac.uk/pdbsum/3rep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rep ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
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===Crystal structure of the ILK/alpha-parvin core complex (MnATP)===
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==See Also==
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*[[Parvin 3D structures|Parvin 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3rep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fukuda, K.]]
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[[Category: Large Structures]]
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[[Category: Qin, J.]]
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[[Category: Fukuda K]]
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[[Category: Qin J]]

Current revision

Crystal structure of the ILK/alpha-parvin core complex (MnATP)

PDB ID 3rep

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