1a3y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1a3y" [edit=sysop:move=sysop])
Current revision (06:21, 30 October 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1a3y.png|left|200px]]
 
-
<!--
+
==ODORANT BINDING PROTEIN FROM NASAL MUCOSA OF PIG==
-
The line below this paragraph, containing "STRUCTURE_1a3y", creates the "Structure Box" on the page.
+
<StructureSection load='1a3y' size='340' side='right'caption='[[1a3y]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1a3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A3Y FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3y OCA], [https://pdbe.org/1a3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a3y RCSB], [https://www.ebi.ac.uk/pdbsum/1a3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3y ProSAT]</span></td></tr>
-
{{STRUCTURE_1a3y| PDB=1a3y | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/OBP_PIG OBP_PIG] This protein is found in nasal epithelium and it binds a wide variety of chemical odorants.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/1a3y_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a3y ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The X-ray structure of the porcine odorant binding protein (OBPp) was determined at 2.25 A resolution. This lipocalin is a monomer and is devoid of naturally occurring bound ligand, contrary to what was observed in the case of bovine OBP [Tegoni, M., et al. (1996) Nat. Struct. Biol. 3, 863-867; Bianchet, M. A., et al. (1996) Nat. Struct. Biol. 3, 934-939]. In this latter protein, a dimer without any disulfide bridges, domain swapping was found to occur between the beta- and alpha-domains. A single Gly (121) insertion was found in OBPp when it was compared to OBPb, which may prevent domain swapping from taking place. The presence of a disulfide bridge between the OBPp beta- and alpha-domains (cysteines 63 and 155) may lock the resulting fold in a nonswapped monomeric conformation. Comparisons with other OBPs indicate that the two cysteines involved in the OBPp disulfide bridge are conserved in the sequence, suggesting that OBPp may be considered a prototypic OBP fold, and not OBPb.
-
===ODORANT BINDING PROTEIN FROM NASAL MUCOSA OF PIG===
+
The structure of the monomeric porcine odorant binding protein sheds light on the domain swapping mechanism.,Spinelli S, Ramoni R, Grolli S, Bonicel J, Cambillau C, Tegoni M Biochemistry. 1998 Jun 2;37(22):7913-8. PMID:9609684<ref>PMID:9609684</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1a3y" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_9609684}}, adds the Publication Abstract to the page
+
*[[Odorant binding protein 3D structures|Odorant binding protein 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 9609684 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_9609684}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[1a3y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3Y OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:009609684</ref><references group="xtra"/>
+
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
-
[[Category: Cambillau, C.]]
+
[[Category: Cambillau C]]
-
[[Category: Spinelli, S.]]
+
[[Category: Spinelli S]]
-
[[Category: Tegoni, M.]]
+
[[Category: Tegoni M]]
-
[[Category: Lipocalin]]
+
-
[[Category: Olfaction]]
+

Current revision

ODORANT BINDING PROTEIN FROM NASAL MUCOSA OF PIG

PDB ID 1a3y

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a3y"
Personal tools