1ahk

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[[Image:1ahk.png|left|200px]]
 
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==DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, MINIMIZED AVERAGE STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1ahk", creates the "Structure Box" on the page.
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<StructureSection load='1ahk' size='340' side='right'caption='[[1ahk]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ahk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AHK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ahk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ahk OCA], [https://pdbe.org/1ahk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ahk RCSB], [https://www.ebi.ac.uk/pdbsum/1ahk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ahk ProSAT]</span></td></tr>
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{{STRUCTURE_1ahk| PDB=1ahk | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALL2_DERFA ALL2_DERFA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/1ahk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ahk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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House dust mites cause heavy atopic diseases such as asthma and dermatitis. Among allergens from Dermatophagoides farinae, Der f 2 shows the highest positive rate for atopic patients, but its biological function in mites has been perfectly unknown, as well as the functions of its homologs in human and other animals. We have determined the tertiary structure of Der f 2 by multidimensional nuclear magnetic resonance spectroscopy. Der f 2 was found to be a single-domain protein of immunoglobulin fold, and its structure was the most similar to those of the two regulatory domains of transglutaminase. This fact, binding to the bacterial surface, and other small pieces of information hinted that Der f 2 is related to the innate antibacterial defense system in mites. The immunoglobulin E epitopes are also discussed on the basis of the tertiary structure.
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===DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, MINIMIZED AVERAGE STRUCTURE===
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Solution structure of Der f 2, the major mite allergen for atopic diseases.,Ichikawa S, Hatanaka H, Yuuki T, Iwamoto N, Kojima S, Nishiyama C, Ogura K, Okumura Y, Inagaki F J Biol Chem. 1998 Jan 2;273(1):356-60. PMID:9417088<ref>PMID:9417088</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9417088}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ahk" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9417088 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_9417088}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1ahk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHK OCA].
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==Reference==
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<ref group="xtra">PMID:009417088</ref><references group="xtra"/>
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[[Category: Dermatophagoides farinae]]
[[Category: Dermatophagoides farinae]]
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[[Category: Hatanaka, H.]]
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[[Category: Large Structures]]
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[[Category: Ichikawa, S.]]
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[[Category: Hatanaka H]]
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[[Category: Inagaki, F.]]
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[[Category: Ichikawa S]]
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[[Category: Iwamoto, N.]]
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[[Category: Inagaki F]]
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[[Category: Ogura, K.]]
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[[Category: Iwamoto N]]
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[[Category: Okumura, Y.]]
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[[Category: Ogura K]]
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[[Category: Yuuki, T.]]
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[[Category: Okumura Y]]
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[[Category: Allergen]]
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[[Category: Yuuki T]]
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[[Category: Immunoglobulin fold]]
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Current revision

DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1ahk

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