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1aho
From Proteopedia
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| - | [[Image:1aho.png|left|200px]] | ||
| - | + | ==THE AB INITIO STRUCTURE DETERMINATION AND REFINEMENT OF A SCORPION PROTEIN TOXIN== | |
| - | + | <StructureSection load='1aho' size='340' side='right'caption='[[1aho]], [[Resolution|resolution]] 0.96Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1aho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_australis_hector Androctonus australis hector]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AHO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.96Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aho OCA], [https://pdbe.org/1aho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aho RCSB], [https://www.ebi.ac.uk/pdbsum/1aho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aho ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/SCX2_ANDAU SCX2_ANDAU] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals. | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | < | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/1aho_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | == | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aho ConSurf]. |
| - | [[1aho]] is a 1 chain structure with sequence from [ | + | <div style="clear:both"></div> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | < | + | |
[[Category: Androctonus australis hector]] | [[Category: Androctonus australis hector]] | ||
| - | [[Category: Blessing | + | [[Category: Large Structures]] |
| - | [[Category: Ealick | + | [[Category: Blessing RH]] |
| - | [[Category: Fontecilla-Camps | + | [[Category: Ealick SE]] |
| - | [[Category: Hauptman | + | [[Category: Fontecilla-Camps JC]] |
| - | [[Category: Housset | + | [[Category: Hauptman HA]] |
| - | [[Category: Langs | + | [[Category: Housset D]] |
| - | [[Category: Miller | + | [[Category: Langs DA]] |
| - | [[Category: Smith | + | [[Category: Miller R]] |
| - | + | [[Category: Smith GD]] | |
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Current revision
THE AB INITIO STRUCTURE DETERMINATION AND REFINEMENT OF A SCORPION PROTEIN TOXIN
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