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1ahl

From Proteopedia

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[[Image:1ahl.png|left|200px]]
 
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==ANTHOPLEURIN-A,NMR, 20 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1ahl", creates the "Structure Box" on the page.
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<StructureSection load='1ahl' size='340' side='right'caption='[[1ahl]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ahl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anthopleura_xanthogrammica Anthopleura xanthogrammica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AHL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ahl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ahl OCA], [https://pdbe.org/1ahl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ahl RCSB], [https://www.ebi.ac.uk/pdbsum/1ahl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ahl ProSAT]</span></td></tr>
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{{STRUCTURE_1ahl| PDB=1ahl | SCENE= }}
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</table>
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== Function ==
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===ANTHOPLEURIN-A,NMR, 20 STRUCTURES===
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[https://www.uniprot.org/uniprot/NA1A_ANTXA NA1A_ANTXA] Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. This toxin retains the greatest capacity to discriminate between the cardiac (Nav1.5/SCN5A) and neuronal sodium channels (2.5 nM versus 120 nM, when electrophysiologically tested and 14 nM versus 400 nM, when tested by ion flux), whereas its paralog Anthopleurin-B has the highest affinity of all anemone toxins for the mammalian sodium channel (PubMed:13806, PubMed:7612595, PubMed:17092528). Its ability to differentiate between cardiac and skeletal channels appears to be associated with domain 4 of the channel (PubMed:9306007). This toxin does not slow or inhibit closed-state inactivation of cardiac sodium channels, but selectively modifies inactivation from the open-state (PubMed:8576699). It does not display phospholipid-binding activities, suggesting that the domain IV S3-S4 linker is located at the extracellular surface and not buried in the phospholipid bilayer (By similarity).[UniProtKB:P01531]<ref>PMID:13806</ref> <ref>PMID:17092528</ref> <ref>PMID:21099342</ref> <ref>PMID:8576699</ref> <ref>PMID:9306007</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 7893675 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/1ahl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_7893675}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ahl ConSurf].
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[[1ahl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anthopleura_xanthogrammica Anthopleura xanthogrammica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHL OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:007893675</ref><ref group="xtra">PMID:011734033</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Anthopleura xanthogrammica]]
[[Category: Anthopleura xanthogrammica]]
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[[Category: Monks, S A.]]
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[[Category: Large Structures]]
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[[Category: Norton, R S.]]
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[[Category: Monks SA]]
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[[Category: Pallaghy, P K.]]
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[[Category: Norton RS]]
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[[Category: Scanlon, M J.]]
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[[Category: Pallaghy PK]]
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[[Category: Cardiac stimulant]]
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[[Category: Scanlon MJ]]
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[[Category: Neurotoxin]]
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Current revision

ANTHOPLEURIN-A,NMR, 20 STRUCTURES

PDB ID 1ahl

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