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1atx

From Proteopedia

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[[Image:1atx.png|left|200px]]
 
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==THREE-DIMENSIONAL STRUCTURE OF THE NEUROTOXIN ATX IA FROM ANEMONIA SULCATA IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY==
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The line below this paragraph, containing "STRUCTURE_1atx", creates the "Structure Box" on the page.
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<StructureSection load='1atx' size='340' side='right'caption='[[1atx]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1atx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anemonia_sulcata Anemonia sulcata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ATX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ATX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1atx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1atx OCA], [https://pdbe.org/1atx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1atx RCSB], [https://www.ebi.ac.uk/pdbsum/1atx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1atx ProSAT]</span></td></tr>
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{{STRUCTURE_1atx| PDB=1atx | SCENE= }}
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</table>
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== Function ==
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===THREE-DIMENSIONAL STRUCTURE OF THE NEUROTOXIN ATX IA FROM ANEMONIA SULCATA IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY===
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[https://www.uniprot.org/uniprot/NA11_ANESU NA11_ANESU] Binds specifically to voltage-gated sodium channels (Nav) and delays their inactivation during signal transduction (when tested on the soma membrane of a crustacean neuron). Has also been observed to affect the activation of the sodium current.<ref>PMID:2409523</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_2576133}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 2576133 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/at/1atx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_2576133}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1atx ConSurf].
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[[1atx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anemonia_sulcata Anemonia sulcata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ATX OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:002576133</ref><ref group="xtra">PMID:011734033</ref><ref group="xtra">PMID:016246732</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Anemonia sulcata]]
[[Category: Anemonia sulcata]]
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[[Category: Billeter, M.]]
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[[Category: Large Structures]]
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[[Category: Widmer, H.]]
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[[Category: Billeter M]]
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[[Category: Wuthrich, K.]]
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[[Category: Widmer H]]
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[[Category: Sea anemone toxin]]
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[[Category: Wuthrich K]]

Current revision

THREE-DIMENSIONAL STRUCTURE OF THE NEUROTOXIN ATX IA FROM ANEMONIA SULCATA IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

PDB ID 1atx

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