2yd9

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[[Image:2yd9.png|left|200px]]
 
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==Crystal structure of the N-terminal Ig1-3 module of Human Receptor Protein Tyrosine Phosphatase Sigma==
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The line below this paragraph, containing "STRUCTURE_2yd9", creates the "Structure Box" on the page.
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<StructureSection load='2yd9' size='340' side='right'caption='[[2yd9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yd9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YD9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_2yd9| PDB=2yd9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yd9 OCA], [https://pdbe.org/2yd9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yd9 RCSB], [https://www.ebi.ac.uk/pdbsum/2yd9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yd9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN] Interacts with LAR-interacting protein LIP.1.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Heparan and chondroitin sulfate proteoglycans (HSPGs and CSPGs) regulate numerous cell surface signaling events, with typically opposite effects on cell function. CSPGs inhibit nerve regeneration through receptor protein tyrosine phosphatase sigma (RPTPsigma). Here, we report that RPTPsigma acts bimodally in sensory neuron extension, mediating CSPG inhibition and HSPG growth promotion. Crystallographic analyses of a shared HSPG-CSPG binding site reveal a conformational plasticity that can accommodate diverse glycosaminoglycans with comparable affinities. Heparan sulfate and analogues induced RPTPsigma ectodomain oligomerization in solution, which chondroitin sulfate inhibited. RPTPsigma and HSPGs colocalize in puncta on sensory neurons in culture, whereas CSPGs occupy the extracellular matrix. These results lead to a model where proteoglycans can exert opposing effects on neuronal extension by competing to control the oligomerization of a common receptor.
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===CRYSTAL STRUCTURE OF THE N-TERMINAL IG1-3 MODULE OF HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE SIGMA===
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Proteoglycan-Specific Molecular Switch for RPTP{sigma} Clustering and Neuronal Extension.,Coles CH, Shen Y, Tenney AP, Siebold C, Sutton GC, Lu W, Gallagher JT, Jones EY, Flanagan JG, Aricescu AR Science. 2011 Mar 31. PMID:21454754<ref>PMID:21454754</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2yd9" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21454754}}, adds the Publication Abstract to the page
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21454754 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21454754}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2yd9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YD9 OCA].
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==Reference==
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<ref group="xtra">PMID:021454754</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Aricescu, A R.]]
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[[Category: Aricescu AR]]
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[[Category: Coles, C H.]]
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[[Category: Coles CH]]
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[[Category: Flanagan, J G.]]
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[[Category: Flanagan JG]]
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[[Category: Gallagher, J T.]]
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[[Category: Gallagher JT]]
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[[Category: Jones, E Y.]]
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[[Category: Jones EY]]
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[[Category: Lu, W.]]
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[[Category: Lu W]]
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[[Category: Shen, Y.]]
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[[Category: Shen Y]]
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[[Category: Siebold, C.]]
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[[Category: Siebold C]]
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[[Category: Sutton, G C.]]
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[[Category: Sutton GC]]
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[[Category: Tenney, A P.]]
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[[Category: Tenney AP]]

Current revision

Crystal structure of the N-terminal Ig1-3 module of Human Receptor Protein Tyrosine Phosphatase Sigma

PDB ID 2yd9

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