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2lce

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'''Unreleased structure'''
 
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The entry 2lce is ON HOLD
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==Chemical shift assignment of Hr4436B from Homo Sapiens, Northeast Structural Genomics Consortium==
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<StructureSection load='2lce' size='340' side='right'caption='[[2lce]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LCE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lce OCA], [https://pdbe.org/2lce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lce RCSB], [https://www.ebi.ac.uk/pdbsum/2lce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lce ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
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== Function ==
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
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Authors: Lee, H., Shastry, R., Ciccosanti, C., Janjua, H., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Prestegard, J.H.
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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Description: Chemical shift assignment of Hr4436B from Homo Sapiens, Northeast
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Acton TB]]
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[[Category: Ciccosanti C]]
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[[Category: Everett JK]]
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[[Category: Janjua H]]
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[[Category: Lee H]]
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[[Category: Montelione GT]]
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[[Category: Prestegard JH]]
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[[Category: Shastry R]]
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[[Category: Xiao R]]

Current revision

Chemical shift assignment of Hr4436B from Homo Sapiens, Northeast Structural Genomics Consortium

PDB ID 2lce

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