241d

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(New page: 200px<br /><applet load="241d" size="350" color="white" frame="true" align="right" spinBox="true" caption="241d, resolution 1.850&Aring;" /> '''EXTENSION OF THE FO...)
Current revision (09:09, 14 February 2024) (edit) (undo)
 
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[[Image:241d.gif|left|200px]]<br /><applet load="241d" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="241d, resolution 1.850&Aring;" />
 
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'''EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)'''<br />
 
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==Overview==
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==EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)==
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The crystal structure of d(CCCAAT), refined at 2.0 A resolution, shows a, four stranded molecule in which two parallel duplexes intercalate with, opposite polarity, using cytosine.protonated cytosine base pairs. The, intercalation motif in this structure is extended by adenine.adenine base, pairs. Two topologically distinct broad grooves are found in the lath-like, central part of the molecule with the phosphate groups on one side bent, over towards each other, stabilized by bridging water molecules. At the 3', ends, two arrangements of intermolecular A.A.T base triplets are found, involving both asymmetric and symmetric A.A base pairs joined to thymine, residues by Watson-Crick and reverse Hoogsteen base pairing, respectively.
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<StructureSection load='241d' size='340' side='right'caption='[[241d]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[241d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=241D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=241D FirstGlance]. <br>
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241D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=241D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=241d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=241d OCA], [https://pdbe.org/241d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=241d RCSB], [https://www.ebi.ac.uk/pdbsum/241d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=241d ProSAT]</span></td></tr>
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==Reference==
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</table>
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Extension of the four-stranded intercalated cytosine motif by adenine.adenine base pairing in the crystal structure of d(CCCAAT)., Berger I, Kang C, Fredian A, Ratliff R, Moyzis R, Rich A, Nat Struct Biol. 1995 May;2(5):416-25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7664099 7664099]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Berger, I.]]
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[[Category: Large Structures]]
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[[Category: Fredian, A.]]
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[[Category: Berger I]]
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[[Category: Kang, C.]]
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[[Category: Fredian A]]
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[[Category: Moyzis, R.]]
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[[Category: Kang C]]
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[[Category: Ratliff, R.]]
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[[Category: Moyzis R]]
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[[Category: Rich, A.]]
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[[Category: Ratliff R]]
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[[Category: arallel-stranded tetraplex]]
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[[Category: Rich A]]
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[[Category: base intercalated]]
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[[Category: mismatched]]
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[[Category: quadruple helix]]
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[[Category: u-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 17:48:40 2008''
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Current revision

EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)

PDB ID 241d

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