3rde

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'''Unreleased structure'''
 
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The entry 3rde is ON HOLD until Paper Publication
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==Crystal structure of the catalytic domain of porcine leukocyte 12-lipoxygenase==
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<StructureSection load='3rde' size='340' side='right'caption='[[3rde]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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Authors: Funk, M.O., Xu, S., Marnett, L.J., Mueser, T.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rde]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RDE FirstGlance]. <br>
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Description: Crystal structure of the catalytic domain of porcine leukocyte 12-lipoxygenase
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.892&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=OYP:3-{4-[(TRIDEC-2-YN-1-YLOXY)METHYL]PHENYL}PROPANOIC+ACID'>OYP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rde OCA], [https://pdbe.org/3rde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rde RCSB], [https://www.ebi.ac.uk/pdbsum/3rde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rde ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LOX15_PIG LOX15_PIG] Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.<ref>PMID:8305485</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Sus scrofa]]
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[[Category: Funk MO]]
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[[Category: Marnett LJ]]
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[[Category: Mueser TC]]
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[[Category: Xu S]]

Current revision

Crystal structure of the catalytic domain of porcine leukocyte 12-lipoxygenase

PDB ID 3rde

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