272d

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(New page: 200px<br /><applet load="272d" size="350" color="white" frame="true" align="right" spinBox="true" caption="272d, resolution 2.000&Aring;" /> '''PARALLEL AND ANTIPA...)
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[[Image:272d.jpg|left|200px]]<br /><applet load="272d" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="272d, resolution 2.000&Aring;" />
 
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'''PARALLEL AND ANTIPARALLEL (G.GC)2 TRIPLE HELIX FRAGMENTS IN A CRYSTAL STRUCTURE'''<br />
 
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==Overview==
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==PARALLEL AND ANTIPARALLEL (G.GC)2 TRIPLE HELIX FRAGMENTS IN A CRYSTAL STRUCTURE==
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Nucleic acid triplexes are formed by sequence-specific interactions, between single-stranded polynucleotides and the double helix. These, triplexes are implicated in genetic recombination in vivo and have, application to areas that include genome analysis and antigene therapy., Despite the importance of the triple helix, only limited high-resolution, structural information is available. The x-ray crystal structure of the, oligonucleotide d(GGCCAATTGG) is described; it was designed to contain the, d(G middle dotGC)2 fragment and thus provide the basic repeat unit of a, DNA triple helix. Parameters derived from this crystal structure have made, it possible to construct models of both parallel and antiparallel triple, helices.
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<StructureSection load='272d' size='340' side='right'caption='[[272d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[272d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=272D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=272D FirstGlance]. <br>
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272D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=272D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=272d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=272d OCA], [https://pdbe.org/272d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=272d RCSB], [https://www.ebi.ac.uk/pdbsum/272d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=272d ProSAT]</span></td></tr>
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==Reference==
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</table>
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Parallel and antiparallel (G.GC)2 triple helix fragments in a crystal structure., Vlieghe D, Van Meervelt L, Dautant A, Gallois B, Precigoux G, Kennard O, Science. 1996 Sep 20;273(5282):1702-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8781231 8781231]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Dautant, A.]]
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[[Category: Large Structures]]
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[[Category: Gallois, B.]]
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[[Category: Dautant A]]
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[[Category: Kennard, O.]]
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[[Category: Gallois B]]
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[[Category: Meervelt, L.Van.]]
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[[Category: Kennard O]]
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[[Category: Precigoux, G.]]
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[[Category: Precigoux G]]
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[[Category: Vlieghe, D.]]
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[[Category: Van Meervelt L]]
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[[Category: b-dna]]
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[[Category: Vlieghe D]]
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[[Category: double helix]]
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[[Category: intermolecular base triplet]]
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[[Category: overhanging bases]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 17:50:09 2008''
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Current revision

PARALLEL AND ANTIPARALLEL (G.GC)2 TRIPLE HELIX FRAGMENTS IN A CRYSTAL STRUCTURE

PDB ID 272d

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