This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3nj4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3nj4" [edit=sysop:move=sysop])
Current revision (10:00, 14 February 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3nj4.jpg|left|200px]]
 
-
<!--
+
==Fluoro-neplanocin A in Human S-Adenosylhomocysteine Hydrolase==
-
The line below this paragraph, containing "STRUCTURE_3nj4", creates the "Structure Box" on the page.
+
<StructureSection load='3nj4' size='340' side='right'caption='[[3nj4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3nj4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NJ4 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AFX:(4S,5S)-4-(6-AMINO-9H-PURIN-9-YL)-3-FLUORO-5-HYDROXY-2-(HYDROXYMETHYL)CYCLOPENT-2-EN-1-ONE'>AFX</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-
{{STRUCTURE_3nj4| PDB=3nj4 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nj4 OCA], [https://pdbe.org/3nj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nj4 RCSB], [https://www.ebi.ac.uk/pdbsum/3nj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nj4 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/SAHH_HUMAN SAHH_HUMAN] Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) [MIM:[https://omim.org/entry/613752 613752]. A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy.<ref>PMID:15024124</ref> <ref>PMID:16736098</ref> <ref>PMID:19177456</ref> <ref>PMID:20852937</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SAHH_HUMAN SAHH_HUMAN] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.<ref>PMID:12590576</ref>
-
===Fluoro-neplanocin A in Human S-Adenosylhomocysteine Hydrolase===
+
==See Also==
-
 
+
*[[S-adenosylhomocysteine hydrolase|S-adenosylhomocysteine hydrolase]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21226494}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 21226494 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_21226494}}
+
-
 
+
-
==About this Structure==
+
-
[[3nj4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NJ4 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:021226494</ref><references group="xtra"/>
+
-
[[Category: Adenosylhomocysteinase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Choi, S.]]
+
[[Category: Large Structures]]
-
[[Category: Heo, Y S.]]
+
[[Category: Choi S]]
-
[[Category: Hwang, K Y.]]
+
[[Category: Heo YS]]
-
[[Category: Jeong, L S.]]
+
[[Category: Hwang KY]]
-
[[Category: Lee, K M.]]
+
[[Category: Jeong LS]]
 +
[[Category: Lee KM]]

Current revision

Fluoro-neplanocin A in Human S-Adenosylhomocysteine Hydrolase

PDB ID 3nj4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3nj4"
Personal tools