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283d

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(New page: 200px<br /><applet load="283d" size="350" color="white" frame="true" align="right" spinBox="true" caption="283d, resolution 2.300&Aring;" /> '''A CURVED RNA HELIX ...)
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[[Image:283d.jpg|left|200px]]<br /><applet load="283d" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="283d, resolution 2.300&Aring;" />
 
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'''A CURVED RNA HELIX INCORPORATING AN INTERNAL LOOP WITH G-A AND A-A NON-WATSON-CRICK BASE PAIRING'''<br />
 
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==Overview==
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==A CURVED RNA HELIX INCORPORATING AN INTERNAL LOOP WITH G-A AND A-A NON-WATSON-CRICK BASE PAIRING==
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The crystal structure of the RNA dodecamer 5'-GGCC(GAAA)GGCC-3' has been, determined from x-ray diffraction data to 2.3-A resolution. In the, crystal, these oligomers form double helices around twofold symmetry axes., Four consecutive non-Watson-Crick base pairs make up an internal loop in, the middle of the duplex, including sheared G.A pairs and novel asymmetric, A.A pairs. This internal loop sequence produces a significant curvature, and narrowing of the double helix. The helix is curved by 34 degrees from, end to end and the diameter is narrowed by 24% in the internal loop. A, Mn2+ ion is bound directly to the N7 of the first guanine in the, Watson-Crick region following the internal loop and the phosphate of the, preceding residue. This Mn2+ location corresponds to a metal binding site, observed in the hammerhead catalytic RNA.
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<StructureSection load='283d' size='340' side='right'caption='[[283d]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[283d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=283D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=283D FirstGlance]. <br>
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283D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MN:'>MN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=283D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=283d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=283d OCA], [https://pdbe.org/283d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=283d RCSB], [https://www.ebi.ac.uk/pdbsum/283d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=283d ProSAT]</span></td></tr>
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A curved RNA helix incorporating an internal loop with G.A and A.A non-Watson-Crick base pairing., Baeyens KJ, De Bondt HL, Pardi A, Holbrook SR, Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12851-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8917508 8917508]
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</table>
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[[Category: ]]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Baeyens, K.J.]]
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[[Category: Large Structures]]
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[[Category: Bondt, H.L.De.]]
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[[Category: Baeyens KJ]]
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[[Category: Holbrook, S.R.]]
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[[Category: De Bondt HL]]
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[[Category: Pardi, A.]]
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[[Category: Holbrook SR]]
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[[Category: MN]]
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[[Category: Pardi A]]
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[[Category: curved]]
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[[Category: double helix]]
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[[Category: internal loop]]
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[[Category: mismatched]]
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[[Category: unusual rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 17:50:36 2008''
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Current revision

A CURVED RNA HELIX INCORPORATING AN INTERNAL LOOP WITH G-A AND A-A NON-WATSON-CRICK BASE PAIRING

PDB ID 283d

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