3av4

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[[Image:3av4.jpg|left|200px]]
 
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==Crystal structure of mouse DNA methyltransferase 1==
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The line below this paragraph, containing "STRUCTURE_3av4", creates the "Structure Box" on the page.
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<StructureSection load='3av4' size='340' side='right'caption='[[3av4]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3av4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AV4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3av4| PDB=3av4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3av4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3av4 OCA], [https://pdbe.org/3av4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3av4 RCSB], [https://www.ebi.ac.uk/pdbsum/3av4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3av4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DNMT1_MOUSE DNMT1_MOUSE] Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.<ref>PMID:11290321</ref> <ref>PMID:15550930</ref> <ref>PMID:17576694</ref>
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===Crystal structure of mouse DNA methyltransferase 1===
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==See Also==
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3av4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AV4 OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Nakagawa, A.]]
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[[Category: Nakagawa A]]
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[[Category: Narita, H.]]
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[[Category: Narita H]]
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[[Category: Suetake, I.]]
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[[Category: Suetake I]]
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[[Category: Suga, M.]]
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[[Category: Suga M]]
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[[Category: Tajima, S.]]
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[[Category: Tajima S]]
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[[Category: Takeshita, K.]]
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[[Category: Takeshita K]]
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[[Category: Yamashita, E.]]
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[[Category: Yamashita E]]

Current revision

Crystal structure of mouse DNA methyltransferase 1

PDB ID 3av4

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OCA

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