293d

[[Image:293d.gif|left|200px]]<br /><applet load="293d" size="350" color="white" frame="true" align="right" spinBox="true"

caption="293d, resolution 1.000&Aring;" />

'''INTERACTION BETWEEN THE LEFT-HANDED Z-DNA AND POLYAMINE-2: THE CRYSTAL STRUCTURE OF THE D(CG)3 AND SPERMIDINE COMPLEX'''<br />

==Overview==

This paper deals with the crystal structure of d(CG)3-spermidine complex., The DNA fragment, d(CG)3, was crystallized with, N-(2-amino-propyl)-1,4-diamino-butane, PA(34), spermidine. The results of, its X-ray crystallographic analysis showed many intermolecular contacts, between d(CG)3 and spermidine, but the binding mode of spermidine to the, d(CG)3 molecule is different from that of the d(CG)3 and, N-(2-amino-ethyl)-1,4-diamino-butane [PA(24)] complex: a spermidine, molecule bound to the d(CG)3 and its symmetrically related neighboring, d(CG)3 molecules through the water molecules with hydrogen bonds, while, one PA(24) molecule connected directly to one d(CG)3 molecule, but not to, its neighboring d(CG)3 molecule. In the crystal, the d(CG)3 molecule was, the left-handed Z-form, and three magnesium cations and a sodium cation, were observed around the d(CG)3 moiety with different binding modes from, the case of the d(CG)3-PA(24) complex.

 

==About this Structure==

293D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SPD:'>SPD</scene>, <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=293D OCA].

 

Interaction between the left-handed Z-DNA and polyamine-2. The crystal structure of the d(CG)3 and spermidine complex., Ohishi H, Nakanishi I, Inubushi K, van der Marel G, van Boom JH, Rich A, Wang AH, Hakoshima T, Tomita K, FEBS Lett. 1996 Aug 5;391(1-2):153-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8706905 8706905]

[[Category: Boom, J.H.Van.]]

[[Category: Hakoshima, T.]]

[[Category: Inubushi, K.]]

[[Category: Marel, G.A.Van.Der.]]

[[Category: Nakanishi, I.]]

[[Category: Ohishi, H.]]

[[Category: Rich, A.]]

[[Category: Tomita, K.]]

[[Category: Wang, A.H.J.]]

[[Category: MG]]

[[Category: NA]]

[[Category: z-dna]]