2a5r

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(New page: 200px<br /><applet load="2a5r" size="350" color="white" frame="true" align="right" spinBox="true" caption="2a5r" /> '''Complex of tetra-(4-n-methylpyridyl) porphin...)
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[[Image:2a5r.gif|left|200px]]<br /><applet load="2a5r" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2a5r" />
 
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'''Complex of tetra-(4-n-methylpyridyl) porphin with monomeric parallel-stranded DNA tetraplex, snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, C-MYC promoter, NMR, 6 struct.'''<br />
 
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==Overview==
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==Complex of tetra-(4-n-methylpyridyl) porphin with monomeric parallel-stranded DNA tetraplex, snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, C-MYC promoter, NMR, 6 struct.==
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It has been widely accepted that DNA can adopt other biologically relevant, structures beside the Watson-Crick double helix. One recent important, example is the guanine-quadruplex (G-quadruplex) structure formed by, guanine tracts found in the MYC (or c-myc) promoter region, which, regulates the transcription of the MYC oncogene. Stabilization of this, G-quadruplex by ligands, such as the cationic porphyrin TMPyP4, decreases, the transcriptional level of MYC. Here, we report the first structure of a, DNA fragment containing five guanine tracts from this region. An unusual, G-quadruplex fold, which was derived from NMR restraints using unambiguous, model-independent resonance assignment approaches, involves a core of, three stacked guanine tetrads formed by four parallel guanine tracts with, all anti guanines and a snapback 3'-end syn guanine. We have determined, the structure of the complex formed between this G-quadruplex and TMPyP4., This structural information, combined with details of small-molecule, interaction, provides a platform for the design of anticancer drugs, targeting multi-guanine-tract sequences that are found in the MYC and, other oncogenic promoters, as well as in telomeres.
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<StructureSection load='2a5r' size='340' side='right'caption='[[2a5r]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2a5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A5R FirstGlance]. <br>
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2A5R is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=POH:'>POH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5R OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=POH:(1Z,4Z,9Z,15Z)-5,10,15,20-TETRAKIS(1-METHYLPYRIDIN-1-IUM-4-YL)-21,23-DIHYDROPORPHYRIN'>POH</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a5r OCA], [https://pdbe.org/2a5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a5r RCSB], [https://www.ebi.ac.uk/pdbsum/2a5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a5r ProSAT]</span></td></tr>
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Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter., Phan AT, Kuryavyi V, Gaw HY, Patel DJ, Nat Chem Biol. 2005 Aug;1(3):167-73. Epub 2005 Jul 17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16408022 16408022]
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</table>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Gaw, H.Y.]]
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[[Category: Gaw HY]]
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[[Category: Kuryavyi, V.V.]]
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[[Category: Kuryavyi VV]]
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[[Category: Patel, D.J.]]
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[[Category: Patel DJ]]
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[[Category: Phan, A.T.]]
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[[Category: Phan AT]]
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[[Category: POH]]
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[[Category: monomeric parallel-stranded quadruplex; c-myc promoter 3+1 g-tetrad; single nucleotide chain reversal loop; gag triad; gaag loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 17:55:00 2008''
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Current revision

Complex of tetra-(4-n-methylpyridyl) porphin with monomeric parallel-stranded DNA tetraplex, snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, C-MYC promoter, NMR, 6 struct.

PDB ID 2a5r

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