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Thiolase

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(New page: Crystal Structure of Thiolase, 2iik {{STRUCTURE_2iik| PDB=2iik | SIZE=300| SCENE= |right|CAPTION=Human 3-ketoacyl-CoA thiolase, 2iik }} '''Th...)
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[[Image:2iik.png|left|200px|thumb|Crystal Structure of Thiolase, [[2iik]]]]
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<StructureSection load='4c2j' size='350' side='right' caption='Human 3-ketoacyl-CoA complex with CoA and ethylene glycol (PDB code [[4c2j]])' scene='44/447919/Cv/7'>
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{{STRUCTURE_2iik| PDB=2iik | SIZE=300| SCENE= |right|CAPTION=Human 3-ketoacyl-CoA thiolase, [[2iik]] }}
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== Function ==
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Two different classes of '''thiolases''' are found.<br />
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'''Thiolase''' involves two different thiolases . The 3-ketoacyl-CoA thiolase (KCT) is involved in fatty acid β oxidation. Acetoacetyl-CoA thiolase (ACT) is involved in the thiolysis of acetoacetyl-CoA.
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*'''Degrative thiolase''' like '''3-ketoacyl-CoA thiolase''' (KCT) is involved in fatty acid [[beta oxidation]]<ref>PMID:16630629</ref>.<br />
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{{TOC limit|limit=2}}
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*'''Biosynthetic thiolases''' like '''acetoacetyl-CoA thiolase''' (ACT) or '''acetyl-CoA acetyltransferase''' are involved in the thiolysis of acetoacetyl-CoA<ref>PMID:21908473</ref>.
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== 3D Structures of Thiolase ==
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For bacterial thiolase see [[Bacterial thiolase]]
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For zebrafish thiolase see [[SCP2-thiolase]]. ''' SCP''' is Sterol Carrier Protein.
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See also [[Mevalonate pathway]]
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== Structural highlights ==
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The <scene name='44/447919/Cv/8'>active site of 3-ketoacyl-CoA thiolase contains CoA</scene><ref>PMID:25478839</ref>. Water molecules are shown as red spheres.
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== 3D Structures of Thiolase ==
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[[Thiolase 3D structures]]
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</StructureSection>
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human 3-ketoacyl-CoA complex with CoA and ethylene glycol (PDB code 4c2j)

Drag the structure with the mouse to rotate

References

  1. ↑ Sundaramoorthy R, Micossi E, Alphey MS, Germain V, Bryce JH, Smith SM, Leonard GA, Hunter WN. The crystal structure of a plant 3-ketoacyl-CoA thiolase reveals the potential for redox control of peroxisomal fatty acid beta-oxidation. J Mol Biol. 2006 Jun 2;359(2):347-57. Epub 2006 Mar 29. PMID:16630629 doi:http://dx.doi.org/10.1016/j.jmb.2006.03.032
  2. ↑ Soto G, Stritzler M, Lisi C, Alleva K, Pagano ME, Ardila F, Mozzicafreddo M, Cuccioloni M, Angeletti M, Ayub ND. Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. J Exp Bot. 2011 Nov;62(15):5699-711. doi: 10.1093/jxb/err287. Epub 2011 Sep 9. PMID:21908473 doi:http://dx.doi.org/10.1093/jxb/err287
  3. ↑ Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK. The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities. Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3212-25. doi:, 10.1107/S1399004714023827. Epub 2014 Nov 22. PMID:25478839 doi:http://dx.doi.org/10.1107/S1399004714023827

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Michal Harel, Joel L. Sussman, Alexander Berchansky

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