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3o9m
From Proteopedia
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| - | [[Image:3o9m.png|left|200px]] | ||
| - | + | ==Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification== | |
| - | + | <StructureSection load='3o9m' size='340' side='right'caption='[[3o9m]], [[Resolution|resolution]] 2.98Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | or the | + | <table><tr><td colspan='2'>[[3o9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O9M FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.98Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o9m OCA], [https://pdbe.org/3o9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o9m RCSB], [https://www.ebi.ac.uk/pdbsum/3o9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o9m ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[https://omim.org/entry/177400 177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Butyrylcholinesterase 3D structures|Butyrylcholinesterase 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Asojo | + | [[Category: Large Structures]] |
| - | [[Category: Homma | + | [[Category: Asojo OA]] |
| - | [[Category: Lockridge | + | [[Category: Homma K]] |
| - | [[Category: Ngamelue | + | [[Category: Lockridge O]] |
| + | [[Category: Ngamelue MN]] | ||
Current revision
Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification
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