3o9m

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[[Image:3o9m.png|left|200px]]
 
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==Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification==
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The line below this paragraph, containing "STRUCTURE_3o9m", creates the "Structure Box" on the page.
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<StructureSection load='3o9m' size='340' side='right'caption='[[3o9m]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3o9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O9M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.98&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
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{{STRUCTURE_3o9m| PDB=3o9m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o9m OCA], [https://pdbe.org/3o9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o9m RCSB], [https://www.ebi.ac.uk/pdbsum/3o9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o9m ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[https://omim.org/entry/177400 177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
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== Function ==
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[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human butyrylcholinesterase (BChE; EC 3.1.1.8) is a 340 kDa tetrameric glycoprotein that is present in human serum at about 5 mg l(-1) and has well documented therapeutic effects on cocaine toxicity. BChE holds promise as a therapeutic that reduces and finally eliminates the rewarding effects of cocaine, thus weaning an addict from the drug. There have been extensive computational studies of cocaine hydrolysis by BChE. Since there are no reported structures of BChE with cocaine or any of the hydrolysis products, full-length monomeric recombinant wild-type BChE was cocrystallized with cocaine. The refined 3 A resolution structure appears to retain the hydrolysis product benzoic acid in sufficient proximity to form a hydrogen bond to the active-site Ser198.
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===Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification===
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Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine.,Asojo OA, Asojo OA, Ngamelue MN, Homma K, Lockridge O Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt, 4):434-7. Epub 2011 Mar 24. PMID:21505234<ref>PMID:21505234</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3o9m" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21505234}}, adds the Publication Abstract to the page
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*[[Butyrylcholinesterase 3D structures|Butyrylcholinesterase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21505234 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21505234}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3o9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9M OCA].
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==Reference==
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<ref group="xtra">PMID:021505234</ref><references group="xtra"/>
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[[Category: Cholinesterase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Asojo, O A.]]
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[[Category: Large Structures]]
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[[Category: Homma, K.]]
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[[Category: Asojo OA]]
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[[Category: Lockridge, O.]]
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[[Category: Homma K]]
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[[Category: Ngamelue, M N.]]
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[[Category: Lockridge O]]
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[[Category: Ngamelue MN]]

Current revision

Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification

PDB ID 3o9m

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