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2kgu

From Proteopedia

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[[Image:2kgu.png|left|200px]]
 
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==Spatial structure of purotoxin-1 in water==
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The line below this paragraph, containing "STRUCTURE_2kgu", creates the "Structure Box" on the page.
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<StructureSection load='2kgu' size='340' side='right'caption='[[2kgu]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kgu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Alopecosa_marikovskyi Alopecosa marikovskyi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KGU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgu OCA], [https://pdbe.org/2kgu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kgu RCSB], [https://www.ebi.ac.uk/pdbsum/2kgu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgu ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_2kgu| PDB=2kgu | SCENE= }}
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== Function ==
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[https://www.uniprot.org/uniprot/TXPR1_ALOMR TXPR1_ALOMR] Inhibits P2RX3 receptors. Has an analgesic effect in rat. Enhances the high-affinity desensitization of P2RX3 receptors. At 50 nM, decreases the IC(50) for ambient ATP from 46.5 nM to 12.7 nM in mouse P2RX3.<ref>PMID:20437566</ref> <ref>PMID:22842000</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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P2X3 purinoreceptors expressed in mammalian sensory neurons play a key role in several processes, including pain perception. From the venom of the Central Asian spider Geolycosa sp., we have isolated a novel peptide, named purotoxin-1 (PT1), which is to our knowledge the first natural molecule exerting powerful and selective inhibitory action on P2X3 receptors. PT1 dramatically slows down the removal of desensitization of these receptors. The peptide demonstrates potent antinociceptive properties in animal models of inflammatory pain.
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===Spatial structure of purotoxin-1 in water===
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Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain.,Grishin EV, Savchenko GA, Vassilevski AA, Korolkova YV, Boychuk YA, Viatchenko-Karpinski VY, Nadezhdin KD, Arseniev AS, Pluzhnikov KA, Kulyk VB, Voitenko NV, Krishtal OO Ann Neurol. 2010 May;67(5):680-3. PMID:20437566<ref>PMID:20437566</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20437566}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2kgu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20437566 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20437566}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Alopecosa marikovskyi]]
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[[2kgu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geolycosa Geolycosa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGU OCA].
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[[Category: Large Structures]]
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[[Category: Arseniev A]]
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==Reference==
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[[Category: Grishin E]]
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<ref group="xtra">PMID:020437566</ref><references group="xtra"/>
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[[Category: Korolkova Y]]
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[[Category: Geolycosa]]
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[[Category: Nadezhdin K]]
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[[Category: Arseniev, A.]]
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[[Category: Pluzhnikov K]]
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[[Category: Grishin, E.]]
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[[Category: Vassilevski A]]
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[[Category: Korolkova, Y.]]
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[[Category: Nadezhdin, K.]]
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[[Category: Pluzhnikov, K.]]
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[[Category: Vassilevski, A.]]
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Current revision

Spatial structure of purotoxin-1 in water

PDB ID 2kgu

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