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2yc2

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[[Image:2yc2.png|left|200px]]
 
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==Intraflagellar Transport Complex 25-27 from Chlamydomonas==
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The line below this paragraph, containing "STRUCTURE_2yc2", creates the "Structure Box" on the page.
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<StructureSection load='2yc2' size='340' side='right'caption='[[2yc2]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yc2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YC2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.588&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_2yc2| PDB=2yc2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yc2 OCA], [https://pdbe.org/2yc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yc2 RCSB], [https://www.ebi.ac.uk/pdbsum/2yc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yc2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IFT25_CHLRE IFT25_CHLRE] Component of the intraflagellar transport (IFT) complex B. Forms a subcomplex within the IFT complex B with IFT27.<ref>PMID:19412537</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The cilium is an important organelle that is found on many eukaryotic cells, where it serves essential functions in motility, sensory reception and signalling. Intraflagellar transport (IFT) is a vital process for the formation and maintenance of cilia. We have determined the crystal structure of Chlamydomonas reinhardtii IFT25/27, an IFT sub-complex, at 2.6 A resolution. IFT25 and IFT27 interact via a conserved interface that we verify biochemically using structure-guided mutagenesis. IFT27 displays the fold of Rab-like small guanosine triphosphate hydrolases (GTPases), binds GTP and GDP with micromolar affinity and has very low intrinsic GTPase activity, suggesting that it likely requires a GTPase-activating protein (GAP) for robust GTP turnover. A patch of conserved surface residues contributed by both IFT25 and IFT27 is found adjacent to the GTP-binding site and could mediate the binding to other IFT proteins as well as to a potential GAP. These results provide the first step towards a high-resolution structural understanding of the IFT complex.
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===INTRAFLAGELLAR TRANSPORT COMPLEX 25-27 FROM CHLAMYDOMONAS===
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Crystal structure of the intraflagellar transport complex 25/27.,Bhogaraju S, Taschner M, Morawetz M, Basquin C, Lorentzen E EMBO J. 2011 Apr 19. PMID:21505417<ref>PMID:21505417</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2yc2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21505417 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21505417}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2yc2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YC2 OCA].
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==Reference==
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<ref group="xtra">PMID:021505417</ref><references group="xtra"/>
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[[Category: Chlamydomonas reinhardtii]]
[[Category: Chlamydomonas reinhardtii]]
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[[Category: Bhogaraju, S.]]
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[[Category: Large Structures]]
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[[Category: Lorentzen, E.]]
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[[Category: Bhogaraju S]]
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[[Category: Taschner, M.]]
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[[Category: Lorentzen E]]
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[[Category: Taschner M]]

Current revision

Intraflagellar Transport Complex 25-27 from Chlamydomonas

PDB ID 2yc2

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