3rn5

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'''Unreleased structure'''
 
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The entry 3rn5 is ON HOLD until Paper Publication
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==Structural basis of cytosolic DNA recognition by innate immune receptors==
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<StructureSection load='3rn5' size='340' side='right'caption='[[3rn5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors: Jin, T.C., Xiao, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rn5]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RN5 FirstGlance]. <br>
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Description: Structural basis of cytosolic DNA recognition by innate immune receptors
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rn5 OCA], [https://pdbe.org/3rn5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rn5 RCSB], [https://www.ebi.ac.uk/pdbsum/3rn5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rn5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AIM2_HUMAN AIM2_HUMAN] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.<ref>PMID:16432157</ref> <ref>PMID:17726700</ref> <ref>PMID:19158679</ref> <ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:20566831</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Jin TC]]
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[[Category: Xiao T]]

Current revision

Structural basis of cytosolic DNA recognition by innate immune receptors

PDB ID 3rn5

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