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3rze
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human histamine H1 receptor in complex with doxepin== | |
| + | <StructureSection load='3rze' size='340' side='right'caption='[[3rze]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3rze]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RZE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5EH:(3E)-3-(DIBENZO[B,E]OXEPIN-11(6H)-YLIDENE)-N,N-DIMETHYLPROPAN-1-AMINE'>5EH</scene>, <scene name='pdbligand=D7V:(3Z)-3-(DIBENZO[B,E]OXEPIN-11(6H)-YLIDENE)-N,N-DIMETHYLPROPAN-1-AMINE'>D7V</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rze OCA], [https://pdbe.org/3rze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rze RCSB], [https://www.ebi.ac.uk/pdbsum/3rze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rze ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HRH1_HUMAN HRH1_HUMAN] In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[G protein-coupled receptor|G protein-coupled receptor]] | |
| - | + | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | |
| + | *[[Neurotransmitters|Neurotransmitters]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia virus T4]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Abagyan R]] | ||
| + | [[Category: Cherezov V]] | ||
| + | [[Category: Han GW]] | ||
| + | [[Category: Iwata S]] | ||
| + | [[Category: Katritch V]] | ||
| + | [[Category: Kobayashi T]] | ||
| + | [[Category: Liu W]] | ||
| + | [[Category: Shimamura T]] | ||
| + | [[Category: Shiroishi M]] | ||
| + | [[Category: Stevens R]] | ||
| + | [[Category: Tsujimoto H]] | ||
| + | [[Category: Weyand S]] | ||
| + | [[Category: Winter G]] | ||
Current revision
Structure of the human histamine H1 receptor in complex with doxepin
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Categories: Escherichia virus T4 | Homo sapiens | Large Structures | Abagyan R | Cherezov V | Han GW | Iwata S | Katritch V | Kobayashi T | Liu W | Shimamura T | Shiroishi M | Stevens R | Tsujimoto H | Weyand S | Winter G
