3rk6

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[[Image:3rk6.jpg|left|200px]]
 
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==Crystal structure of the middle domain of human Paip1==
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The line below this paragraph, containing "STRUCTURE_3rk6", creates the "Structure Box" on the page.
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<StructureSection load='3rk6' size='340' side='right'caption='[[3rk6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RK6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rk6 OCA], [https://pdbe.org/3rk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rk6 RCSB], [https://www.ebi.ac.uk/pdbsum/3rk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rk6 ProSAT]</span></td></tr>
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{{STRUCTURE_3rk6| PDB=3rk6 | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of the middle domain of human Paip1===
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[https://www.uniprot.org/uniprot/PAIP1_HUMAN PAIP1_HUMAN] Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.<ref>PMID:9548260</ref> <ref>PMID:11051545</ref>
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== References ==
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<references/>
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21539810 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21539810}}
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==About this Structure==
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[[3rk6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RK6 OCA].
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==Reference==
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<ref group="xtra">PMID:021539810</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hilgenfeld, R.]]
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[[Category: Large Structures]]
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[[Category: Lei, J.]]
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[[Category: Hilgenfeld R]]
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[[Category: Mesters, J R.]]
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[[Category: Lei J]]
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[[Category: Mesters JR]]

Current revision

Crystal structure of the middle domain of human Paip1

PDB ID 3rk6

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OCA

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