2wfk

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[[Image:2wfk.png|left|200px]]
 
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==Calcium bound LipL32==
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The line below this paragraph, containing "STRUCTURE_2wfk", creates the "Structure Box" on the page.
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<StructureSection load='2wfk' size='340' side='right'caption='[[2wfk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wfk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Leptospira_santarosai_serovar_Shermani Leptospira santarosai serovar Shermani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2wfk| PDB=2wfk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfk OCA], [https://pdbe.org/2wfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wfk RCSB], [https://www.ebi.ac.uk/pdbsum/2wfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q6S9S1_9LEPT Q6S9S1_9LEPT]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tubulointerstitial nephritis is a cardinal renal manifestation of leptospirosis. LipL32, a major lipoprotein and a virulence factor, locates on the outer membrane of the pathogen Leptospira. It evades immune response by recognizing and adhering to extracellular matrix components of the host cell. The crystal structure of Ca(2+)-bound LipL32 was determined at 2.3 A resolution. LipL32 has a novel polyD sequence of seven aspartates that forms a continuous acidic surface patch for Ca(2+) binding. A significant conformational change was observed for the Ca(2+)-bound form of LipL32. Calcium binding to LipL32 was determined by isothermal titration calorimetry. The binding of fibronectin to LipL32 was observed by Stains-all CD and enzyme-linked immunosorbent assay experiments. The interaction between LipL32 and fibronectin might be associated with Ca(2+) binding. Based on the crystal structure of Ca(2+)-bound LipL32 and the Stains-all results, fibronectin probably binds near the polyD region on LipL32. Ca(2+) binding to LipL32 might be important for Leptospira to interact with the extracellular matrix of the host cell.
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===CALCIUM BOUND LIPL32===
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Calcium binds to LipL32, a lipoprotein from pathogenic Leptospira, and modulates fibronectin binding.,Tung JY, Yang CW, Chou SW, Lin CC, Sun YJ J Biol Chem. 2010 Jan 29;285(5):3245-52. Epub 2009 Nov 30. PMID:19948735<ref>PMID:19948735</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19948735}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wfk" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19948735 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19948735}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2wfk]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Leptospira_santarosai_serovar_shermani Leptospira santarosai serovar shermani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFK OCA].
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[[Category: Leptospira santarosai serovar Shermani]]
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[[Category: Sun Y-J]]
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==Reference==
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[[Category: Tung J-Y]]
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<ref group="xtra">PMID:019948735</ref><references group="xtra"/>
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[[Category: Yang C-W]]
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[[Category: Leptospira santarosai serovar shermani]]
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[[Category: Sun, Y J.]]
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[[Category: Tung, J Y.]]
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[[Category: Yang, C W.]]
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Current revision

Calcium bound LipL32

PDB ID 2wfk

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