3ajy

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[[Image:3ajy.jpg|left|200px]]
 
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==Crystal Structure of Ancestral Congerin Con-anc==
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The line below this paragraph, containing "STRUCTURE_3ajy", creates the "Structure Box" on the page.
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<StructureSection load='3ajy' size='340' side='right'caption='[[3ajy]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ajy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AJY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene></td></tr>
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{{STRUCTURE_3ajy| PDB=3ajy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ajy OCA], [https://pdbe.org/3ajy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ajy RCSB], [https://www.ebi.ac.uk/pdbsum/3ajy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ajy ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ancestral structures of fish galectins (congerins) were determined. The extant isoforms I and II of congerin are the components of a fish biological defense system and have rapidly differentiated under natural selection pressure, by which congerin I has experienced a protein-fold evolution. The dimer structure of the ancestral congerin demonstrated intermediate features of the extant isoforms. The protein-fold evolution was not observed in the ancestral structure, indicating it specifically occurred in congerin I lineage. Details of hydrogen bonding pattern at the dimer interface and the carbohydrate-binding site of the ancestor were different from the current proteins. The differences implied these proteins were under selection pressure for stabilizing dimer structure and differentiation in carbohydrate specificity. The ancestor had rather low cytotoxic activity than offspring, indicating selection was made to enhance this activity of congerins. Combined with functional analyses, the structure revealed atomic details of the differentiation process of the proteins.
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===Crystal Structure of Ancestral Congerin Con-anc===
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Tracing protein evolution through ancestral structures of fish galectin.,Konno A, Kitagawa A, Watanabe M, Ogawa T, Shirai T Structure. 2011 May 11;19(5):711-21. PMID:21565705<ref>PMID:21565705</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3ajy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJY OCA].
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<div class="pdbe-citations 3ajy" style="background-color:#fffaf0;"></div>
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[[Category: Kitagawa, A.]]
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== References ==
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[[Category: Konno, A.]]
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<references/>
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[[Category: Ogawa, T.]]
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__TOC__
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[[Category: Shirai, T.]]
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</StructureSection>
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[[Category: Watanabe, M.]]
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[[Category: Large Structures]]
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[[Category: Kitagawa A]]
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[[Category: Konno A]]
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[[Category: Ogawa T]]
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[[Category: Shirai T]]
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[[Category: Watanabe M]]

Current revision

Crystal Structure of Ancestral Congerin Con-anc

PDB ID 3ajy

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