3ru0

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[[Image:3ru0.jpg|left|200px]]
 
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==Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound==
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The line below this paragraph, containing "STRUCTURE_3ru0", creates the "Structure Box" on the page.
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<StructureSection load='3ru0' size='340' side='right'caption='[[3ru0]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ru0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RU0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.849&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3ru0| PDB=3ru0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ru0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ru0 OCA], [https://pdbe.org/3ru0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ru0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ru0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ru0 ProSAT]</span></td></tr>
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</table>
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===Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound===
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== Function ==
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[https://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref>
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== References ==
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==About this Structure==
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<references/>
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[[3ru0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RU0 OCA].
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__TOC__
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[[Category: Histone-lysine N-methyltransferase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arnold, L.]]
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[[Category: Large Structures]]
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[[Category: Brown, M.]]
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[[Category: Arnold L]]
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[[Category: Crew, A.]]
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[[Category: Brown M]]
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[[Category: Das, C.]]
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[[Category: Crew A]]
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[[Category: Emtage, S.]]
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[[Category: Das C]]
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[[Category: Foreman, K W.]]
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[[Category: Emtage S]]
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[[Category: Harriss, J.]]
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[[Category: Foreman KW]]
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[[Category: Park, F.]]
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[[Category: Harriss J]]
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[[Category: Shaaban, S.]]
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[[Category: Park F]]
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[[Category: Tucker, P.]]
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[[Category: Shaaban S]]
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[[Category: Zhu, L.]]
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[[Category: Tucker P]]
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[[Category: Zhu L]]

Current revision

Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound

PDB ID 3ru0

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