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2rrm

From Proteopedia

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[[Image:2rrm.jpg|left|200px]]
 
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==Interplay between phosphatidyl-inositol-phosphates and claudins upon binding to the 1st PDZ domain of zonula occludens 1==
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The line below this paragraph, containing "STRUCTURE_2rrm", creates the "Structure Box" on the page.
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<StructureSection load='2rrm' size='340' side='right'caption='[[2rrm]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rrm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rrm OCA], [https://pdbe.org/2rrm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rrm RCSB], [https://www.ebi.ac.uk/pdbsum/2rrm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rrm ProSAT]</span></td></tr>
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</table>
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{{STRUCTURE_2rrm| PDB=2rrm | SCENE= }}
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== Function ==
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[https://www.uniprot.org/uniprot/ZO1_MOUSE ZO1_MOUSE] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Zonula occludens-1 (ZO-1) is a scaffolding molecule critical to the formation of intercellular adhesion structures, such as tight junctions (TJs) and adherens junctions (AJs). ZO-1 contains three PDZ domains followed by a GUK domain and a ZU5 domain. The first PDZ of ZO-1 (ZO-1(PDZ1)) serves as a protein-protein interaction module and interacts with the C-termini of almost all claudins to initiate the formation of a belt-like structure on the lateral membranes, thereby promoting TJ formation. It has been recently reported that approximately 15% of all PDZ domains bind phosphoinositides, and ZO-1(PDZ1) is the one of these. Here we report the (15)N, (13)C, and (1)H chemical shift assignments of the first PDZ domain of mouse ZO-1. The resonance assignments obtained in this work may contribute in clarifying the interplay between the two binary interactions, ZO-1(PDZ1)-claudins and ZO-1(PDZ1)-phospholipids, and suggesting a novel regulation mechanism underlying the formation and maintenance of cell-cell adhesion machinery downstream of the phospholipid signaling pathways.
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===Interplay between phosphatidyl-inositol-phosphates and claudins upon binding to the 1st PDZ domain of zonula occludens 1===
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(1)H, (13)C, and (15)N resonance assignment of the first PDZ domain of mouse ZO-1.,Umetsu Y, Goda N, Taniguchi R, Satomura K, Ikegami T, Furuse M, Hiroaki H Biomol NMR Assign. 2011 Mar 24. PMID:21431884<ref>PMID:21431884</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21431884}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2rrm" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21431884 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21431884}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2rrm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRM OCA].
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==Reference==
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<ref group="xtra">PMID:021431884</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Furuse, M.]]
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[[Category: Furuse M]]
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[[Category: Goda, N.]]
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[[Category: Goda N]]
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[[Category: Hiroaki, H.]]
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[[Category: Hiroaki H]]
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[[Category: Ikegami, T.]]
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[[Category: Ikegami T]]
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[[Category: Satomura, k.]]
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[[Category: Satomura K]]
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[[Category: Taniguchi, R.]]
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[[Category: Taniguchi R]]
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[[Category: Umetsu, Y.]]
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[[Category: Umetsu Y]]

Current revision

Interplay between phosphatidyl-inositol-phosphates and claudins upon binding to the 1st PDZ domain of zonula occludens 1

PDB ID 2rrm

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