2cwo

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(New page: 200px<br /><applet load="2cwo" size="350" color="white" frame="true" align="right" spinBox="true" caption="2cwo, resolution 3.30&Aring;" /> '''Crystal structure of...)
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[[Image:2cwo.gif|left|200px]]<br /><applet load="2cwo" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2cwo, resolution 3.30&Aring;" />
 
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'''Crystal structure of RNA silencing suppressor p21 from Beet Yellows Virus'''<br />
 
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==Overview==
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==Crystal structure of RNA silencing suppressor p21 from Beet Yellows Virus==
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Many plant viruses encode proteins that suppress the antiviral RNA, silencing response mounted by the host. The suppressors p19 from, tombusvirus and p21 from Beet yellows virus appear to block silencing by, directly binding siRNA, a critical mediator in the process. Here, we, report the crystal structure of p21, which reveals an octameric ring, architecture with a large central cavity of approximately 90 A diameter., The all alpha-helical p21 monomer consists of N- and C-terminal domains, that associate with their neighboring counterparts through symmetric, head-to-head and tail-to-tail interactions. A putative RNA binding surface, is identified in the conserved, positive-charged inner surface of the, ring. In contrast to the specific p19-siRNA duplex interaction, p21 is a, general nucleic acid binding protein, interacting with 21 nt or longer, single- and double-stranded RNAs in vitro. This study reveals an RNA, binding structure adopted by the p21 silencing suppressor.
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<StructureSection load='2cwo' size='340' side='right'caption='[[2cwo]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2cwo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Beet_yellows_virus Beet yellows virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CWO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cwo OCA], [https://pdbe.org/2cwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cwo RCSB], [https://www.ebi.ac.uk/pdbsum/2cwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cwo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P21_BYVU P21_BYVU] Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to ssRNAs and dsRNAs in vitro. Also functions as replication enhancer.<ref>PMID:12642093</ref>
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==About this Structure==
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==See Also==
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2CWO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Beet_yellows_virus Beet yellows virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CWO OCA].
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*[[RNA silencing suppressor|RNA silencing suppressor]]
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== References ==
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==Reference==
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<references/>
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RNA silencing suppressor p21 of Beet yellows virus forms an RNA binding octameric ring structure., Ye K, Patel DJ, Structure. 2005 Sep;13(9):1375-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16154094 16154094]
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__TOC__
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</StructureSection>
[[Category: Beet yellows virus]]
[[Category: Beet yellows virus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Patel, D.J.]]
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[[Category: Patel DJ]]
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[[Category: Ye, K.]]
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[[Category: Ye K]]
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[[Category: all alpha helical]]
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[[Category: head-to-head]]
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[[Category: octamer]]
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[[Category: ring]]
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[[Category: rna-binding protein]]
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[[Category: tail-to-tail]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 18:49:54 2008''
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Current revision

Crystal structure of RNA silencing suppressor p21 from Beet Yellows Virus

PDB ID 2cwo

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