3gf7

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[[Image:3gf7.png|left|200px]]
 
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==Glutaconyl-coA decarboxylase A subunit from Clostridium symbiosum apoprotein==
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The line below this paragraph, containing "STRUCTURE_3gf7", creates the "Structure Box" on the page.
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<StructureSection load='3gf7' size='340' side='right'caption='[[3gf7]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gf7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_symbiosum Clostridium symbiosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GF7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3gf7| PDB=3gf7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf7 OCA], [https://pdbe.org/3gf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gf7 RCSB], [https://www.ebi.ac.uk/pdbsum/3gf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gf7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B7TVP1_CLOSY B7TVP1_CLOSY]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/3gf7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gf7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glutaconyl-CoA decarboxylase (Gcd) couples the biotin-dependent decarboxylation of glutaconyl-CoA with the generation of an electrochemical Na(+) gradient. Sequencing of the genes encoding all subunits of the Clostridium symbiosum decarboxylase membrane complex revealed that it comprises two distinct biotin carrier subunits, GcdC(1) and GcdC(2), which differ in the length of a central alanine- and proline-rich linker domain. Co-crystallization of the decarboxylase subunit GcdA with the substrate glutaconyl-CoA, the product crotonyl-CoA, and the substrate analogue glutaryl-CoA, respectively, resulted in a high resolution model for substrate binding and catalysis revealing remarkable structural changes upon substrate binding. Unlike the GcdA structure from Acidaminococcus fermentans, these data suggest that in intact Gcd complexes, GcdA is associated as a tetramer crisscrossed by a network of solvent-filled tunnels.
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===Glutaconyl-coA decarboxylase A subunit from Clostridium symbiosum apoprotein===
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An asymmetric model for Na+-translocating glutaconyl-CoA decarboxylases.,Kress D, Brugel D, Schall I, Linder D, Buckel W, Essen LO J Biol Chem. 2009 Oct 9;284(41):28401-9. Epub 2009 Aug 4. PMID:19654317<ref>PMID:19654317</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_019654317}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3gf7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 019654317 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_019654317}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3gf7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_symbiosum Clostridium symbiosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF7 OCA].
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[[Category: Brugel D]]
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[[Category: Buckel W]]
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==Reference==
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[[Category: Essen L-O]]
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<ref group="xtra">PMID:019654317</ref><references group="xtra"/>
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[[Category: Kress D]]
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[[Category: Clostridium symbiosum]]
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[[Category: Glutaconyl-CoA decarboxylase]]
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[[Category: Brugel, D.]]
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[[Category: Buckel, W.]]
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[[Category: Essen, L O.]]
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[[Category: Kress, D.]]
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[[Category: Biotin]]
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[[Category: Glutaconyl-coa decarboxylase]]
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[[Category: Glutamate fermentation]]
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[[Category: Lyase]]
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[[Category: Sodium ion transport]]
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Current revision

Glutaconyl-coA decarboxylase A subunit from Clostridium symbiosum apoprotein

PDB ID 3gf7

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Proteopedia Page Contributors and Editors (what is this?)

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