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3gre

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[[Image:3gre.png|left|200px]]
 
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==Crystal structure of Saccharomyces cerevisiae Vps15 WD repeat domain==
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The line below this paragraph, containing "STRUCTURE_3gre", creates the "Structure Box" on the page.
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<StructureSection load='3gre' size='340' side='right'caption='[[3gre]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gre]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GRE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gre OCA], [https://pdbe.org/3gre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gre RCSB], [https://www.ebi.ac.uk/pdbsum/3gre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gre ProSAT]</span></td></tr>
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{{STRUCTURE_3gre| PDB=3gre | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VPS15_YEAST VPS15_YEAST] Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole.<ref>PMID:1988155</ref> <ref>PMID:3062374</ref> <ref>PMID:1756716</ref> <ref>PMID:8387919</ref> <ref>PMID:8509446</ref> <ref>PMID:7989323</ref> <ref>PMID:8649377</ref> <ref>PMID:11157979</ref> <ref>PMID:12244127</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/3gre_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gre ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Saccharomyces cerevisiae Vps15 WD repeat domain===
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_19445518}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 19445518 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_19445518}}
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[[Category: Large Structures]]
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==About this Structure==
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[[3gre]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GRE OCA].
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==Reference==
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<ref group="xtra">PMID:019445518</ref><references group="xtra"/>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Betts, L.]]
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[[Category: Betts L]]
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[[Category: Sondek, J.]]
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[[Category: Sondek J]]
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[[Category: Vanhooke, J L.]]
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[[Category: Vanhooke JL]]
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[[Category: Atp-binding]]
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[[Category: Endosome]]
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[[Category: Golgi apparatus]]
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[[Category: Kinase]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Myristate]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Protein binding]]
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[[Category: Protein transport]]
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[[Category: Scaffold protein]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Seven-bladed propeller]]
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[[Category: Signaling protein]]
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[[Category: Transferase]]
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[[Category: Transport]]
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[[Category: Wd repeat]]
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Current revision

Crystal structure of Saccharomyces cerevisiae Vps15 WD repeat domain

PDB ID 3gre

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OCA

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