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3ham

From Proteopedia

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[[Image:3ham.png|left|200px]]
 
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==Structure of the gentamicin-APH(2")-IIa complex==
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The line below this paragraph, containing "STRUCTURE_3ham", creates the "Structure Box" on the page.
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<StructureSection load='3ham' size='340' side='right'caption='[[3ham]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ham]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HAM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LLL:(2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDROXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL'>LLL</scene></td></tr>
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{{STRUCTURE_3ham| PDB=3ham | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ham FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ham OCA], [https://pdbe.org/3ham PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ham RCSB], [https://www.ebi.ac.uk/pdbsum/3ham PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ham ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9EVD7_ENTFC Q9EVD7_ENTFC]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/3ham_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ham ConSurf].
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<div style="clear:both"></div>
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===Structure of the gentamicin-APH(2")-IIa complex===
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==See Also==
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*[[Phosphotransferase|Phosphotransferase]]
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*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_19429619}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 19429619 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19429619}}
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==About this Structure==
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[[3ham]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAM OCA].
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==Reference==
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<ref group="xtra">PMID:019429619</ref><references group="xtra"/>
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[[Category: Enterococcus faecium]]
[[Category: Enterococcus faecium]]
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[[Category: Baker, E N.]]
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[[Category: Large Structures]]
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[[Category: Smith, C A.]]
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[[Category: Baker EN]]
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[[Category: Vakulenko, S B.]]
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[[Category: Smith CA]]
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[[Category: Young, P G.]]
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[[Category: Vakulenko SB]]
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[[Category: Aminoglycoside]]
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[[Category: Young PG]]
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[[Category: Antibiotic resistance]]
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[[Category: Gentamicin]]
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[[Category: Transferase]]
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Current revision

Structure of the gentamicin-APH(2")-IIa complex

PDB ID 3ham

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OCA

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