3hg1

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[[Image:3hg1.png|left|200px]]
 
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==Germline-governed recognition of a cancer epitope by an immunodominant human T cell receptor==
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The line below this paragraph, containing "STRUCTURE_3hg1", creates the "Structure Box" on the page.
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<StructureSection load='3hg1' size='340' side='right'caption='[[3hg1]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hg1]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HG1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3hg1| PDB=3hg1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hg1 OCA], [https://pdbe.org/3hg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hg1 RCSB], [https://www.ebi.ac.uk/pdbsum/3hg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hg1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8WLS4_HUMAN Q8WLS4_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/3hg1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hg1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CD8(+) T-cells specific for MART-1-(26-35), a dominant melanoma epitope restricted by human leukocyte antigen (HLA)-A*0201, are exceptionally common in the naive T-cell repertoire. Remarkably, the TRAV12-2 gene is used to encode the T-cell receptor alpha (TCRalpha) chain in &gt;87% of these T-cells. Here, the molecular basis for this genetic bias is revealed from the structural and thermodynamic properties of an archetypal TRAV12-2-encoded TCR complexed to the clinically relevant heteroclitic peptide, ELAGIGILTV, bound to HLA-A*0201 (A2-ELA). Unusually, the TRAV12-2 germ line-encoded regions of the TCR dominate the major atomic contacts with the peptide at the TCR/A2-ELA interface. This "innate" pattern of antigen recognition probably explains the unique characteristics and extraordinary frequencies of CD8(+) T-cell responses to this epitope.
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===Germline-governed recognition of a cancer epitope by an immunodominant human T cell receptor===
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Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.,Cole DK, Yuan F, Rizkallah PJ, Miles JJ, Gostick E, Price DA, Gao GF, Jakobsen BK, Sewell AK J Biol Chem. 2009 Oct 2;284(40):27281-9. Epub 2009 Jul 15. PMID:19605354<ref>PMID:19605354</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3hg1" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19605354}}, adds the Publication Abstract to the page
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19605354 is the PubMed ID number.
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*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_19605354}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3hg1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HG1 OCA].
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==Reference==
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<ref group="xtra">PMID:019605354</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cole, D K.]]
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[[Category: Large Structures]]
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[[Category: Gao, G F.]]
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[[Category: Cole DK]]
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[[Category: Gostick, E.]]
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[[Category: Gao GF]]
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[[Category: Jakobsen, B K.]]
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[[Category: Gostick E]]
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[[Category: Miles, J J.]]
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[[Category: Jakobsen BK]]
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[[Category: Price, D A.]]
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[[Category: Miles JJ]]
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[[Category: Rizkallah, P J.]]
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[[Category: Price DA]]
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[[Category: Sewell, A K.]]
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[[Category: Rizkallah PJ]]
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[[Category: Yuan, F.]]
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[[Category: Sewell AK]]
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[[Category: Cdr3]]
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[[Category: Yuan F]]
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[[Category: Disease mutation]]
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[[Category: Disulfide bond]]
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[[Category: Glycation]]
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[[Category: Glycoprotein]]
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[[Category: Immune response]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin domain]]
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[[Category: Mart-1]]
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[[Category: Melan-1]]
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[[Category: Mhc i]]
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[[Category: Phage display]]
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[[Category: Pyrrolidone carboxylic acid]]
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[[Category: Secreted]]
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[[Category: T-cell receptor]]
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[[Category: Transmembrane]]
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Current revision

Germline-governed recognition of a cancer epitope by an immunodominant human T cell receptor

PDB ID 3hg1

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