2w18

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:17, 3 January 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2w18.png|left|200px]]
 
-
<!--
+
==Crystal structure of the C-terminal WD40 domain of human PALB2==
-
The line below this paragraph, containing "STRUCTURE_2w18", creates the "Structure Box" on the page.
+
<StructureSection load='2w18' size='340' side='right'caption='[[2w18]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2w18]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W18 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
{{STRUCTURE_2w18| PDB=2w18 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w18 OCA], [https://pdbe.org/2w18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w18 RCSB], [https://www.ebi.ac.uk/pdbsum/2w18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w18 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/PALB2_HUMAN PALB2_HUMAN] Defects in PALB2 are a cause of susceptibility to breast cancer (BC) [MIM:[https://omim.org/entry/114480 114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Note=Breast cancer susceptibility is strongly associated with PALB2 truncating mutations. Conversely, rare missense mutations do not strongly influence breast cancer risk (PubMed:22241545). Defects in PALB2 are the cause of Fanconi anemia complementation group N (FANCN) [MIM:[https://omim.org/entry/610832 610832]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.<ref>PMID:17200672</ref> Defects in PALB2 are the cause of pancreatic cancer type 3 (PNCA3) [MIM:[https://omim.org/entry/613348 613348]. It is a malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.<ref>PMID:19264984</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PALB2_HUMAN PALB2_HUMAN] Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures.<ref>PMID:16793542</ref> <ref>PMID:19423707</ref> <ref>PMID:19369211</ref> <ref>PMID:20871615</ref> <ref>PMID:20871616</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The breast cancer 2, early onset protein (BRCA2) is central to the repair of DNA damage by homologous recombination. BRCA2 recruits the recombinase RAD51 to sites of damage, regulates its assembly into nucleoprotein filaments and thereby promotes homologous recombination. Localization of BRCA2 to nuclear foci requires its association with the partner and localizer of BRCA2 (PALB2), mutations in which are associated with cancer predisposition, as well as subtype N of Fanconi anaemia. We have determined the structure of the PALB2 carboxy-terminal beta-propeller domain in complex with a BRCA2 peptide. The structure shows the molecular determinants of this important protein-protein interaction and explains the effects of both cancer-associated truncating mutants in PALB2 and missense mutations in the amino-terminal region of BRCA2.
-
===CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF HUMAN PALB2===
+
Structural basis for recruitment of BRCA2 by PALB2.,Oliver AW, Swift S, Lord CJ, Ashworth A, Pearl LH EMBO Rep. 2009 Sep;10(9):990-6. Epub 2009 Jul 17. PMID:19609323<ref>PMID:19609323</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_19609323}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2w18" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 19609323 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_19609323}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
[[2w18]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W18 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:019609323</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Oliver, A W.]]
+
[[Category: Large Structures]]
-
[[Category: Pearl, L H.]]
+
[[Category: Oliver AW]]
-
[[Category: Beta-propeller]]
+
[[Category: Pearl LH]]
-
[[Category: Coiled coil]]
+
-
[[Category: Fanc-n]]
+
-
[[Category: Fanconi anemia]]
+
-
[[Category: Homologous recomination]]
+
-
[[Category: Nuclear protein]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Wd repeat]]
+
-
[[Category: Wd40]]
+

Current revision

Crystal structure of the C-terminal WD40 domain of human PALB2

PDB ID 2w18

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2w18"
Personal tools