2wmd

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[[Image:2wmd.png|left|200px]]
 
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==Crystal structure of NmrA-like family domain containing protein 1 in complex with NADP and 2-(4-chloro-phenylamino)-nicotinic acid==
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The line below this paragraph, containing "STRUCTURE_2wmd", creates the "Structure Box" on the page.
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<StructureSection load='2wmd' size='340' side='right'caption='[[2wmd]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wmd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WMD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZZ0:2-(4-CHLORO-PHENYLAMINO)-NICOTINIC+ACID'>ZZ0</scene></td></tr>
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{{STRUCTURE_2wmd| PDB=2wmd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmd OCA], [https://pdbe.org/2wmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wmd RCSB], [https://www.ebi.ac.uk/pdbsum/2wmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wmd ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF NMRA-LIKE FAMILY DOMAIN CONTAINING PROTEIN 1 IN COMPLEX WITH NADP AND 2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID===
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== Function ==
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[https://www.uniprot.org/uniprot/NMRL1_HUMAN NMRL1_HUMAN] Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.<ref>PMID:18263583</ref> <ref>PMID:17496144</ref> <ref>PMID:19254724</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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[[2wmd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMD OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wmd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wmd ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Bhatia, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bountra, C.]]
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[[Category: Bhatia C]]
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[[Category: Delft, F Von.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Filippakopoulos P]]
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[[Category: Heightman, T.]]
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[[Category: Heightman T]]
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[[Category: Hozjan, V.]]
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[[Category: Hozjan V]]
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[[Category: Niesen, F.]]
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[[Category: Niesen F]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Pilka, E.]]
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[[Category: Pilka E]]
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[[Category: Roos, A K.]]
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[[Category: Roos AK]]
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[[Category: Savitsky, P.]]
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[[Category: Savitsky P]]
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[[Category: Ugochukwu, E.]]
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[[Category: Ugochukwu E]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Yue, W W.]]
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[[Category: Yue WW]]
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[[Category: Disulfide bond]]
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[[Category: Von Delft F]]
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[[Category: Oxidoreductase]]
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[[Category: Polymorphism]]
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Current revision

Crystal structure of NmrA-like family domain containing protein 1 in complex with NADP and 2-(4-chloro-phenylamino)-nicotinic acid

PDB ID 2wmd

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