2d4r

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(New page: 200px<br /><applet load="2d4r" size="350" color="white" frame="true" align="right" spinBox="true" caption="2d4r, resolution 2.40&Aring;" /> '''Crystal structure of...)
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[[Image:2d4r.gif|left|200px]]<br /><applet load="2d4r" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2d4r, resolution 2.40&Aring;" />
 
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'''Crystal structure of TTHA0849 from Thermus thermophilus HB8'''<br />
 
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==Overview==
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==Crystal structure of TTHA0849 from Thermus thermophilus HB8==
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The crystal structure of a conserved hypothetical protein, TTHA0849 from, Thermus thermophilus HB8, has been determined at 2.4 A resolution as a, part of a structural and functional genomics project on T. thermophilus, HB8. The main-chain folding shows a compact alpha+beta motif, forming a, hydrophobic cavity in the molecule. A structural similarity search reveals, that it resembles those steroidogenic acute regulatory proteins that, contain the lipid-transfer (START) domain, even though TTHA0849 shows, comparatively weak sequence identity to polyketide cyclases. However, the, size of the ligand-binding cavity is distinctly smaller than other START, domain-containing proteins, suggesting that it catalyses the transfer of, smaller ligand molecules.
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<StructureSection load='2d4r' size='340' side='right'caption='[[2d4r]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2d4r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D4R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d4r OCA], [https://pdbe.org/2d4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d4r RCSB], [https://www.ebi.ac.uk/pdbsum/2d4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d4r ProSAT], [https://www.topsan.org/Proteins/RSGI/2d4r TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5SK03_THET8 Q5SK03_THET8]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d4/2d4r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d4r ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, has been determined at 2.4 A resolution as a part of a structural and functional genomics project on T. thermophilus HB8. The main-chain folding shows a compact alpha+beta motif, forming a hydrophobic cavity in the molecule. A structural similarity search reveals that it resembles those steroidogenic acute regulatory proteins that contain the lipid-transfer (START) domain, even though TTHA0849 shows comparatively weak sequence identity to polyketide cyclases. However, the size of the ligand-binding cavity is distinctly smaller than other START domain-containing proteins, suggesting that it catalyses the transfer of smaller ligand molecules.
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==About this Structure==
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Structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, at 2.4 A resolution: a putative member of the StAR-related lipid-transfer (START) domain superfamily.,Nakabayashi M, Shibata N, Komori H, Ueda Y, Iino H, Ebihara A, Kuramitsu S, Higuchi Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Dec 1;61(Pt, 12):1027-31. Epub 2005 Nov 5. PMID:16511226<ref>PMID:16511226</ref>
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2D4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D4R OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, at 2.4 A resolution: a putative member of the StAR-related lipid-transfer (START) domain superfamily., Nakabayashi M, Shibata N, Komori H, Ueda Y, Iino H, Ebihara A, Kuramitsu S, Higuchi Y, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2005 Dec 1;61(Pt, 12):1027-31. Epub 2005 Nov 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16511226 16511226]
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</div>
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[[Category: Single protein]]
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<div class="pdbe-citations 2d4r" style="background-color:#fffaf0;"></div>
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[[Category: Thermus thermophilus]]
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== References ==
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[[Category: Higuchi, Y.]]
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<references/>
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[[Category: Kuramitsu, S.]]
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__TOC__
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[[Category: Nakabayashi, M.]]
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</StructureSection>
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[[Category: Large Structures]]
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[[Category: Shibata, N.]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: SO4]]
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[[Category: Higuchi Y]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Kuramitsu S]]
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[[Category: rsgi]]
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[[Category: Nakabayashi M]]
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[[Category: start domain]]
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[[Category: Shibata N]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 18:55:20 2008''
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Current revision

Crystal structure of TTHA0849 from Thermus thermophilus HB8

PDB ID 2d4r

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