3niq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3niq" [edit=sysop:move=sysop])
Current revision (16:46, 1 November 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3niq.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of Pseudomonas aeruginosa guanidinopropionase==
-
The line below this paragraph, containing "STRUCTURE_3niq", creates the "Structure Box" on the page.
+
<StructureSection load='3niq' size='340' side='right'caption='[[3niq]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3niq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NIQ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-
{{STRUCTURE_3niq| PDB=3niq | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3niq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3niq OCA], [https://pdbe.org/3niq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3niq RCSB], [https://www.ebi.ac.uk/pdbsum/3niq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3niq ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GPUA_PSEAE GPUA_PSEAE] Catalyzes the hydrolysis of 3-guanidinopropanoate to beta-alanine and urea. Possesses low activity against 4-guanidinobutanoate. Has no activity against arginine and agmatine.<ref>PMID:21600989</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Pseudomonas aeruginosa guanidinobutyrase (GbuA) and guanidinopropionase (GpuA) catalyze the hydrolysis of 4-guanidinobutyrate and 3-guanidinopropionate, respectively. They belong to the ureohydrolase superfamily, which includes arginase, agmatinase, proclavaminate amidinohydrolase, and formiminoglutamase. In this study, we have determined the crystal structures of GbuA and GpuA from P. aeruginosa to provide a structural insight into their substrate specificity. Although GbuA and GpuA share a common structural fold of the typical ureohydrolase superfamily, they exhibit significant variations in two active site loops. Mutagenesis of Met161 of GbuA and Tyr157 of GpuA, both of which are located in the active site loop 1 and predicted to be involved in substrate recognition, significantly affected their enzymatic properties, implying their important roles in catalysis.
-
===Crystal structure of Pseudomonas aeruginosa guanidinopropionase===
+
Crystal structures of Pseudomonas aeruginosa guanidinobutyrase and guanidinopropionase, members of the ureohydrolase superfamily.,Lee SJ, Kim DJ, Kim HS, Lee BI, Yoon HJ, Yoon JY, Kim KH, Jang JY, Im HN, An DR, Song JS, Kim HJ, Suh SW J Struct Biol. 2011 May 12. PMID:21600989<ref>PMID:21600989</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21600989}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3niq" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 21600989 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_21600989}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[3niq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIQ OCA].
+
[[Category: Pseudomonas aeruginosa PAO1]]
-
 
+
[[Category: An D]]
-
==Reference==
+
[[Category: Im H]]
-
<ref group="xtra">PMID:021600989</ref><references group="xtra"/>
+
[[Category: Jang JY]]
-
[[Category: Guanidinopropionase]]
+
[[Category: Kim DJ]]
-
[[Category: Pseudomonas aeruginosa]]
+
[[Category: Kim HS]]
-
[[Category: An, D.]]
+
[[Category: Kim KH]]
-
[[Category: Im, H.]]
+
[[Category: Lee SJ]]
-
[[Category: Jang, J Y.]]
+
[[Category: Suh SW]]
-
[[Category: Kim, D J.]]
+
[[Category: Yoon HJ]]
-
[[Category: Kim, H S.]]
+
[[Category: Yoon JY]]
-
[[Category: Kim, K H.]]
+
-
[[Category: Lee, S J.]]
+
-
[[Category: Suh, S W.]]
+
-
[[Category: Yoon, H J.]]
+
-
[[Category: Yoon, J Y.]]
+

Current revision

Crystal structure of Pseudomonas aeruginosa guanidinopropionase

PDB ID 3niq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3niq"
Personal tools