3p91
From Proteopedia
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| - | [[Image:3p91.jpg|left|200px]] | ||
| - | < | + | ==Crystal structure of Proliferating Cellular Nuclear Antigen from Entamoeba histolytica== |
| - | + | <StructureSection load='3p91' size='340' side='right'caption='[[3p91]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3p91]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica Entamoeba histolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P91 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p91 OCA], [https://pdbe.org/3p91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p91 RCSB], [https://www.ebi.ac.uk/pdbsum/3p91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p91 ProSAT]</span></td></tr> |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/C4M9R9_ENTH1 C4M9R9_ENTH1] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.[RuleBase:RU000641] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Proliferating cellular nuclear antigen (PCNA) is a toroidal-shaped protein that is involved in cell-cycle control, DNA replication and DNA repair. Parasitic protozoa are early-diverged eukaryotes that are responsible for neglected diseases. In this work, a PCNA from a parasitic protozoon was identified, cloned and biochemically characterized and its crystal structure was determined. Structural and biochemical studies demonstrate that PCNA from Entamoeba histolytica assembles as a homotrimer that is able to interact with and stimulate the activity of a PCNA-interacting peptide-motif protein from E. histolytica, EhDNAligI. The data indicate a conservation of the biochemical mechanisms of PCNA-mediated interactions between metazoa, yeast and parasitic protozoa. | ||
| - | + | Structure and biochemical characterization of proliferating cellular nuclear antigen from a parasitic protozoon.,Cardona-Felix CS, Lara-Gonzalez S, Brieba LG Acta Crystallogr D Biol Crystallogr. 2011 Jun;67(Pt 6):497-505. Epub 2011 May 12. PMID:21636889<ref>PMID:21636889</ref> | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 3p91" style="background-color:#fffaf0;"></div> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Entamoeba histolytica]] | [[Category: Entamoeba histolytica]] | ||
| - | [[Category: Brieba | + | [[Category: Large Structures]] |
| - | [[Category: Cardona-Felix | + | [[Category: Brieba LG]] |
| - | [[Category: Lara-Gonzalez | + | [[Category: Cardona-Felix CS]] |
| + | [[Category: Lara-Gonzalez S]] | ||
Current revision
Crystal structure of Proliferating Cellular Nuclear Antigen from Entamoeba histolytica
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