3s86
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of TM0159 with bound IMP== | |
| + | <StructureSection load='3s86' size='340' side='right'caption='[[3s86]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3s86]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S86 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s86 OCA], [https://pdbe.org/3s86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s86 RCSB], [https://www.ebi.ac.uk/pdbsum/3s86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s86 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IXTPA_THEMA IXTPA_THEMA] Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.[HAMAP-Rule:MF_01405] | ||
| - | + | ==See Also== | |
| - | + | *[[Nucleoside triphosphatase|Nucleoside triphosphatase]] | |
| - | + | *[[Sandbox 30008|Sandbox 30008]] | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thermotoga maritima]] | ||
| + | [[Category: Awwad K]] | ||
| + | [[Category: Desai A]] | ||
| + | [[Category: Smith C]] | ||
| + | [[Category: Sommerhalter M]] | ||
Current revision
Crystal Structure of TM0159 with bound IMP
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