3sai
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3sai is ON HOLD Authors: Anderson, A. C., Beierlein, J. M Description: Bacuills anthracis Dihydrofolate Reductase bound to propargyl-linked TMP ana...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Bacuills anthracis Dihydrofolate Reductase bound to propargyl-linked TMP analog, UCP1015== | |
| + | <StructureSection load='3sai' size='340' side='right'caption='[[3sai]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3sai]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SAI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9DR:6-ETHYL-5-{3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]PROP-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>9DR</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sai OCA], [https://pdbe.org/3sai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sai RCSB], [https://www.ebi.ac.uk/pdbsum/3sai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sai ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q81R22_BACAN Q81R22_BACAN] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] | ||
| - | + | ==See Also== | |
| - | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Bacillus anthracis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Anderson AC]] | ||
| + | [[Category: Beierlein JM]] | ||
Current revision
Bacuills anthracis Dihydrofolate Reductase bound to propargyl-linked TMP analog, UCP1015
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