2rrq

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[[Image:2rrq.jpg|left|200px]]
 
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==DNA oligomer containing propylene cross-linked cyclic 2'-deoxyuridylate dimer==
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The line below this paragraph, containing "STRUCTURE_2rrq", creates the "Structure Box" on the page.
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<StructureSection load='2rrq' size='340' side='right'caption='[[2rrq]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rrq]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JDT:2-DEOXY-5-ETHYLURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>JDT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rrq OCA], [https://pdbe.org/2rrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rrq RCSB], [https://www.ebi.ac.uk/pdbsum/2rrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rrq ProSAT]</span></td></tr>
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{{STRUCTURE_2rrq| PDB=2rrq | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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High Mobility Group Box 1 (HMGB1) protein, a potential therapeutic target, binds bent DNAs structure-specifically. Here we report on a crucial structural feature of the bent DNA required for strong binding to HMGB1. NMR structures of two bent DNA oligomers, only one of which binds strongly to HMGB1, revealed that the presence of a pocket structure on the minor groove is crucial for strong binding through penetration of a phenylalanine residue.
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===DNA oligomer containing propylene cross-linked cyclic 2'-deoxyuridylate dimer===
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Structural feature of bent DNA recognized by HMGB1.,Furuita K, Murata S, Jee JG, Ichikawa S, Matsuda A, Kojima C J Am Chem Soc. 2011 Apr 20;133(15):5788-90. Epub 2011 Mar 28. PMID:21443191<ref>PMID:21443191</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21443191}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2rrq" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21443191 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21443191}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2rrq]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRQ OCA].
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[[Category: Furuita K]]
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[[Category: Ichikawa S]]
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==Reference==
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[[Category: Jee JG]]
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<ref group="xtra">PMID:021443191</ref><references group="xtra"/>
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[[Category: Kojima C]]
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[[Category: Furuita, K.]]
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[[Category: Matsuda A]]
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[[Category: Ichikawa, S.]]
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[[Category: Murata S]]
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[[Category: Jee, J G.]]
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[[Category: Kojima, C.]]
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[[Category: Matsuda, A.]]
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[[Category: Murata, S.]]
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Current revision

DNA oligomer containing propylene cross-linked cyclic 2'-deoxyuridylate dimer

PDB ID 2rrq

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