3rlq

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[[Image:3rlq.jpg|left|200px]]
 
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==Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5- carbonitrile==
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The line below this paragraph, containing "STRUCTURE_3rlq", creates the "Structure Box" on the page.
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<StructureSection load='3rlq' size='340' side='right'caption='[[3rlq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rlq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RLQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3RQ:4-(2,4-DICHLORO-5-METHOXYPHENYL)-2-METHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONITRILE'>3RQ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3rlq| PDB=3rlq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rlq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rlq OCA], [https://pdbe.org/3rlq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rlq RCSB], [https://www.ebi.ac.uk/pdbsum/3rlq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rlq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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===Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5- carbonitrile===
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21612924}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21612924 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21612924}}
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==About this Structure==
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[[3rlq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RLQ OCA].
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==Reference==
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<ref group="xtra">PMID:021612924</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bergqvist, S.]]
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[[Category: Large Structures]]
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[[Category: Gajiwala, K S.]]
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[[Category: Bergqvist S]]
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[[Category: Hickey, M J.]]
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[[Category: Gajiwala KS]]
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[[Category: Huang, B.]]
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[[Category: Hickey MJ]]
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[[Category: Kania, R.]]
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[[Category: Huang B]]
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[[Category: Kung, P-P.]]
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[[Category: Kania R]]
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[[Category: Maegley, K.]]
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[[Category: Kung P-P]]
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[[Category: McClellan, G.]]
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[[Category: Maegley K]]
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[[Category: Mehta, P P.]]
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[[Category: McClellan G]]
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[[Category: Richardson, P.]]
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[[Category: Mehta PP]]
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[[Category: Sinnema, P-J.]]
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[[Category: Richardson P]]
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[[Category: Wang, F.]]
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[[Category: Sinnema P-J]]
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[[Category: Wang, J.]]
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[[Category: Wang F]]
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[[Category: Wang J]]

Current revision

Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5- carbonitrile

PDB ID 3rlq

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