2e9e

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(New page: 200px<br /><applet load="2e9e" size="350" color="white" frame="true" align="right" spinBox="true" caption="2e9e, resolution 3.25&Aring;" /> '''Crystal structure of...)
Current revision (05:11, 17 October 2024) (edit) (undo)
 
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[[Image:2e9e.jpg|left|200px]]<br /><applet load="2e9e" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2e9e, resolution 3.25&Aring;" />
 
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'''Crystal structure of the complex of goat lactoperoxidase with Nitrate at 3.25 A resolution'''<br />
 
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==About this Structure==
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==Crystal structure of the complex of goat lactoperoxidase with Nitrate at 3.25 A resolution==
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2E9E is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus] with <scene name='pdbligand=NO3:'>NO3</scene>, <scene name='pdbligand=CO3:'>CO3</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CYN:'>CYN</scene>, <scene name='pdbligand=SCN:'>SCN</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=OSM:'>OSM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E9E OCA].
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<StructureSection load='2e9e' size='340' side='right'caption='[[2e9e]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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[[Category: Capra hircus]]
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== Structural highlights ==
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[[Category: Peroxidase]]
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<table><tr><td colspan='2'>[[2e9e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E9E FirstGlance]. <br>
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[[Category: Protein complex]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
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[[Category: Bhushan, A.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=OSM:1-(OXIDOSULFANYL)METHANAMINE'>OSM</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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[[Category: Kaur, P.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e9e OCA], [https://pdbe.org/2e9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e9e RCSB], [https://www.ebi.ac.uk/pdbsum/2e9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e9e ProSAT]</span></td></tr>
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[[Category: Sharma, S.]]
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</table>
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[[Category: Singh, A.K.]]
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== Function ==
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[[Category: Singh, N.]]
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[https://www.uniprot.org/uniprot/PERL_CAPHI PERL_CAPHI] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).<ref>PMID:10894086</ref>
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[[Category: Singh, S.B.]]
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== Evolutionary Conservation ==
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[[Category: Singh, T.P.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: kumar, R.Prem.]]
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Check<jmol>
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[[Category: CA]]
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<jmolCheckbox>
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[[Category: CO3]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/2e9e_consurf.spt"</scriptWhenChecked>
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[[Category: CYN]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: HEM]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: NO3]]
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</jmolCheckbox>
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[[Category: OSM]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e9e ConSurf].
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[[Category: SCN]]
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<div style="clear:both"></div>
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[[Category: complex]]
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[[Category: lactoperoxidase]]
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[[Category: milk protein]]
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[[Category: nitrate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:17:22 2008''
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==See Also==
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*[[Lactoperoxidase|Lactoperoxidase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Capra hircus]]
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[[Category: Large Structures]]
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[[Category: Bhushan A]]
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[[Category: Kaur P]]
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[[Category: Prem kumar R]]
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[[Category: Sharma S]]
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[[Category: Singh AK]]
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[[Category: Singh N]]
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[[Category: Singh SB]]
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[[Category: Singh TP]]

Current revision

Crystal structure of the complex of goat lactoperoxidase with Nitrate at 3.25 A resolution

PDB ID 2e9e

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