3qzs

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[[Image:3qzs.jpg|left|200px]]
 
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==Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form I==
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The line below this paragraph, containing "STRUCTURE_3qzs", creates the "Structure Box" on the page.
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<StructureSection load='3qzs' size='340' side='right'caption='[[3qzs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qzs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QZS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
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{{STRUCTURE_3qzs| PDB=3qzs | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzs OCA], [https://pdbe.org/3qzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qzs RCSB], [https://www.ebi.ac.uk/pdbsum/3qzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qzs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Little is known about how combinations of histone marks are interpreted at the level of nucleosomes. The second PHD finger of human BPTF is known to specifically recognize histone H3 when methylated on lysine 4 (H3K4me2/3). Here, we examine how additional heterotypic modifications influence BPTF binding. Using peptide surrogates, three acetyllysine ligands are indentified for a PHD-adjacent bromodomain in BPTF via systematic screening and biophysical characterization. Although the bromodomain displays limited discrimination among the three possible acetyllysines at the peptide level, marked selectivity is observed for only one of these sites, H4K16ac, in combination with H3K4me3 at the mononucleosome level. In support, these two histone marks constitute a unique trans-histone modification pattern that unambiguously resides within a single nucleosomal unit in human cells, and this module colocalizes with these marks in the genome. Together, our data call attention to nucleosomal patterning of covalent marks in dictating critical chromatin associations.
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===Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form I===
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Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions.,Ruthenburg AJ, Li H, Milne TA, Dewell S, McGinty RK, Yuen M, Ueberheide B, Dou Y, Muir TW, Patel DJ, Allis CD Cell. 2011 May 27;145(5):692-706. Epub 2011 May 19. PMID:21596426<ref>PMID:21596426</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qzs" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21596426}}, adds the Publication Abstract to the page
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*[[Histone 3D structures|Histone 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21596426 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21596426}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3qzs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZS OCA].
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==Reference==
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<ref group="xtra">PMID:021596426</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, H.]]
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[[Category: Large Structures]]
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[[Category: Patel, D J.]]
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[[Category: Xenopus laevis]]
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[[Category: Ruthenburg, A J.]]
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[[Category: Li H]]
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[[Category: Protein-peptide complex]]
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[[Category: Patel DJ]]
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[[Category: Transcription-nuclear protein complex]]
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[[Category: Ruthenburg AJ]]

Current revision

Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form I

PDB ID 3qzs

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