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2rnm

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[[Image:2rnm.png|left|200px]]
 
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==Structure of The HET-s(218-289) prion in its amyloid form obtained by solid-state NMR==
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The line below this paragraph, containing "STRUCTURE_2rnm", creates the "Structure Box" on the page.
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<StructureSection load='2rnm' size='340' side='right'caption='[[2rnm]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2rnm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Podospora_anserina Podospora anserina]. The May 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Prions'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_5 10.2210/rcsb_pdb/mom_2008_5]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnm OCA], [https://pdbe.org/2rnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rnm RCSB], [https://www.ebi.ac.uk/pdbsum/2rnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rnm ProSAT]</span></td></tr>
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{{STRUCTURE_2rnm| PDB=2rnm | SCENE= }}
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</table>
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== Function ==
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===Structure of The HET-s(218-289) prion in its amyloid form obtained by solid-state NMR===
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[https://www.uniprot.org/uniprot/HETS_PODAS HETS_PODAS] Responsible for heterokaryon incompatibility, a process that ensures that during spontaneous, vegetative cell fusion only compatible cells from the same colony survive (non-self-recognition). Forms a prion for the non-Mendelian trait [het-s]. Interacts with het-S from incompatible cells to trigger a lethal reaction that prevents the formation of viable heterokaryons. It is unknown if the native, soluble protein has a cellular function.<ref>PMID:1886611</ref> <ref>PMID:8224826</ref> <ref>PMID:9275200</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 18339938 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18339938}}
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==About this Structure==
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[[2rnm]] is a 5 chain structure of [[Prion]] and [[Prion protein]] with sequence from [http://en.wikipedia.org/wiki/Podospora_anserina Podospora anserina]. The May 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Prions'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_5 10.2210/rcsb_pdb/mom_2008_5]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNM OCA].
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==See Also==
==See Also==
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*[[Prion]]
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*[[Prion 3D structures|Prion 3D structures]]
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*[[Prion protein]]
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*[[Prion protein|Prion protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018339938</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Podospora anserina]]
[[Category: Podospora anserina]]
[[Category: Prions]]
[[Category: Prions]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Lange, A.]]
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[[Category: Lange A]]
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[[Category: Meier, B H.]]
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[[Category: Meier BH]]
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[[Category: Melckebeke, H Van.]]
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[[Category: Riek R]]
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[[Category: Riek, R.]]
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[[Category: Siemer A]]
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[[Category: Siemer, A.]]
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[[Category: Van Melckebeke H]]
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[[Category: Wasmer, C.]]
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[[Category: Wasmer C]]
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[[Category: Amyloid fibril]]
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[[Category: Asparagine ladder]]
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[[Category: Beta-helix]]
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[[Category: Beta-solenoid]]
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[[Category: Hydrophobic core]]
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[[Category: Parallel beta-sheet]]
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[[Category: Prion]]
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[[Category: Protein fibril]]
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[[Category: Salt bridge]]
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Current revision

Structure of The HET-s(218-289) prion in its amyloid form obtained by solid-state NMR

PDB ID 2rnm

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