3kas

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[[Image:3kas.png|left|200px]]
 
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==Machupo virus GP1 bound to human transferrin receptor 1==
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The line below this paragraph, containing "STRUCTURE_3kas", creates the "Structure Box" on the page.
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<StructureSection load='3kas' size='340' side='right'caption='[[3kas]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kas]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mammarenavirus_machupoense Mammarenavirus machupoense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KAS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3kas| PDB=3kas | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kas OCA], [https://pdbe.org/3kas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kas RCSB], [https://www.ebi.ac.uk/pdbsum/3kas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kas ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8AZ57_MACHU Q8AZ57_MACHU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/3kas_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kas ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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New World hemorrhagic fever arenaviruses are rodent-borne agents that cause severe human disease. The GP1 subunit of the surface glycoprotein mediates cell attachment through transferrin receptor 1 (TfR1). We report the structure of Machupo virus (MACV) GP1 bound with human TfR1. Atomic details of the GP1-TfR1 interface clarify the importance of TfR1 residues implicated in New World arenavirus host specificity. Analysis of sequence variation among New World arenavirus GP1s and their host-species receptors, in light of the molecular structure, indicates determinants of viral zoonotic transmission. Infectivities of pseudoviruses in cells expressing mutated TfR1 confirm that contacts at the tip of the TfR1 apical domain determine the capacity of human TfR1 to mediate infection by particular New World arenaviruses. We propose that New World arenaviruses that are pathogenic to humans fortuitously acquired affinity for human TfR1 during adaptation to TfR1 of their natural hosts.
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===Machupo virus GP1 bound to human transferrin receptor 1===
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Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses.,Abraham J, Corbett KD, Farzan M, Choe H, Harrison SC Nat Struct Mol Biol. 2010 Apr;17(4):438-44. Epub 2010 Mar 7. PMID:20208545<ref>PMID:20208545</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3kas" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20208545}}, adds the Publication Abstract to the page
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*[[Glycoprotein GP 3D structures|Glycoprotein GP 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20208545 is the PubMed ID number.
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*[[Transferrin receptor|Transferrin receptor]]
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== References ==
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{{ABSTRACT_PUBMED_20208545}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3kas]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Machupo_virus Machupo virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KAS OCA].
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==Reference==
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<ref group="xtra">PMID:020208545</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Machupo virus]]
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[[Category: Large Structures]]
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[[Category: Abraham, J.]]
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[[Category: Mammarenavirus machupoense]]
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[[Category: Corbett, K D.]]
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[[Category: Abraham J]]
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[[Category: Harrison, S C.]]
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[[Category: Corbett KD]]
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[[Category: Arenavirus]]
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[[Category: Harrison SC]]
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[[Category: Cell membrane]]
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[[Category: Disulfide bond]]
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[[Category: Endocytosis]]
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[[Category: Glycoprotein]]
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[[Category: Host-virus interaction]]
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[[Category: Machupo virus]]
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[[Category: Receptor]]
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[[Category: Secreted]]
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[[Category: Transferrin receptor 1]]
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[[Category: Transmembrane]]
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[[Category: Viral protein-endocytosis complex]]
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Current revision

Machupo virus GP1 bound to human transferrin receptor 1

PDB ID 3kas

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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