3izq

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[[Image:3izq.jpg|left|200px]]
 
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==Structure of the Dom34-Hbs1-GDPNP complex bound to a translating ribosome==
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The line below this paragraph, containing "STRUCTURE_3izq", creates the "Structure Box" on the page.
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<SX load='3izq' size='340' side='right' viewer='molstar' caption='[[3izq]], [[Resolution|resolution]] 9.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3izq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IZQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izq OCA], [https://pdbe.org/3izq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3izq RCSB], [https://www.ebi.ac.uk/pdbsum/3izq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3izq ProSAT]</span></td></tr>
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{{STRUCTURE_3izq| PDB=3izq | SCENE= }}
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</table>
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== Function ==
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===Structure of the Dom34-Hbs1-GDPNP complex bound to a translating ribosome===
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[https://www.uniprot.org/uniprot/DOM34_YEAST DOM34_YEAST] Involved in protein translation. Together with HBS1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. The complex formed by DOM34 and HBS1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of HBS1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions.<ref>PMID:16554824</ref> <ref>PMID:17889667</ref> <ref>PMID:18180287</ref>
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21623367 is the PubMed ID number.
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_21623367}}
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==About this Structure==
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[[3izq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZQ OCA].
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==Reference==
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<ref group="xtra">PMID:021623367</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Anger, A M.]]
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[[Category: Abdel Motaal B]]
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[[Category: Armache, J P.]]
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[[Category: Anger AM]]
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[[Category: Becker, T.]]
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[[Category: Armache J-P]]
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[[Category: Beckmann, R.]]
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[[Category: Becker T]]
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[[Category: Berninghausen, O.]]
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[[Category: Beckmann R]]
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[[Category: Jarasch, A.]]
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[[Category: Berninghausen O]]
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[[Category: Mielke, T.]]
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[[Category: Jarasch A]]
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[[Category: Motaal, B Abdel.]]
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[[Category: Mielke T]]
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[[Category: Sieber, H.]]
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[[Category: Sieber H]]
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[[Category: Villa, E.]]
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[[Category: Villa E]]
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[[Category: Hydrolase]]
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[[Category: No-go mrna decay]]
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[[Category: Ribosomal protein]]
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Current revision

Structure of the Dom34-Hbs1-GDPNP complex bound to a translating ribosome

3izq, resolution 9.50Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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