3n9z

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[[Image:3n9z.jpg|left|200px]]
 
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==Crystal structure of human CYP11A1 in complex with 22-hydroxycholesterol==
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The line below this paragraph, containing "STRUCTURE_3n9z", creates the "Structure Box" on the page.
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<StructureSection load='3n9z' size='340' side='right'caption='[[3n9z]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3n9z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N9Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HC9:(3ALPHA,8ALPHA,22R)-CHOLEST-5-ENE-3,22-DIOL'>HC9</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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{{STRUCTURE_3n9z| PDB=3n9z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n9z OCA], [https://pdbe.org/3n9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n9z RCSB], [https://www.ebi.ac.uk/pdbsum/3n9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n9z ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CP11A_HUMAN CP11A_HUMAN] Inherited isolated adrenal insufficiency due to CYP11A1 deficiency;46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CP11A_HUMAN CP11A_HUMAN] Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.<ref>PMID:21636783</ref>
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===Crystal structure of human CYP11A1 in complex with 22-hydroxycholesterol===
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==See Also==
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*[[Ferredoxin 3D structures|Ferredoxin 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21636783 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21636783}}
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==About this Structure==
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[[3n9z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N9Z OCA].
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==Reference==
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<ref group="xtra">PMID:021636783</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Botchkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Botchkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Bountra C]]
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[[Category: MacKenzie, F.]]
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[[Category: Edwards AM]]
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[[Category: Park, H.]]
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[[Category: MacKenzie F]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Park H]]
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[[Category: Strushkevich, N V.]]
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[[Category: Strushkevich NV]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Weigelt, J U.]]
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[[Category: Weigelt JU]]
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[[Category: 22-hydroxycholesterol]]
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[[Category: Cholesterol side chain cleavage]]
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[[Category: Cytochrome p450]]
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[[Category: Electron transport]]
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[[Category: Oxidoreductase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal structure of human CYP11A1 in complex with 22-hydroxycholesterol

PDB ID 3n9z

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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